| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PMM1331 | pepA | PMM1331 | PMM1332 | Conserved hypothetical protein; Alternative locus ID: PMED4_14991. | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.760 |
| PMM1331 | tyrS | PMM1331 | PMM1329 | Conserved hypothetical protein; Alternative locus ID: PMED4_14991. | Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. | 0.619 |
| aspC | cysK1 | PMM0674 | PMM0407 | Aminotransferases class-I; Possible role in phosphonate metabolism; Alternative locus ID: PMED4_07301. | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_04501; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.903 |
| aspC | cysK2 | PMM0674 | PMM0123 | Aminotransferases class-I; Possible role in phosphonate metabolism; Alternative locus ID: PMED4_07301. | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_01291; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.903 |
| aspC | pepA | PMM0674 | PMM1332 | Aminotransferases class-I; Possible role in phosphonate metabolism; Alternative locus ID: PMED4_07301. | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.816 |
| aspC | pepN | PMM0674 | PMM1002 | Aminotransferases class-I; Possible role in phosphonate metabolism; Alternative locus ID: PMED4_07301. | Probable aminopeptidase N; Alternative locus ID: PMED4_11281. | 0.802 |
| cysK1 | aspC | PMM0407 | PMM0674 | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_04501; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Aminotransferases class-I; Possible role in phosphonate metabolism; Alternative locus ID: PMED4_07301. | 0.903 |
| cysK1 | cysK2 | PMM0407 | PMM0123 | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_04501; Belongs to the cysteine synthase/cystathionine beta- synthase family. | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_01291; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.907 |
| cysK1 | metH | PMM0407 | PMM0877 | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_04501; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.888 |
| cysK1 | pepA | PMM0407 | PMM1332 | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_04501; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.815 |
| cysK1 | pepN | PMM0407 | PMM1002 | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_04501; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Probable aminopeptidase N; Alternative locus ID: PMED4_11281. | 0.816 |
| cysK2 | aspC | PMM0123 | PMM0674 | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_01291; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Aminotransferases class-I; Possible role in phosphonate metabolism; Alternative locus ID: PMED4_07301. | 0.903 |
| cysK2 | cysK1 | PMM0123 | PMM0407 | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_01291; Belongs to the cysteine synthase/cystathionine beta- synthase family. | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_04501; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.907 |
| cysK2 | metH | PMM0123 | PMM0877 | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_01291; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.888 |
| cysK2 | pepA | PMM0123 | PMM1332 | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_01291; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.809 |
| cysK2 | pepN | PMM0123 | PMM1002 | O-acetylserine (thiol)-lyase A; Alternative locus ID: PMED4_01291; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Probable aminopeptidase N; Alternative locus ID: PMED4_11281. | 0.815 |
| gloB | gshB | PMM0559 | PMM0178 | Putative hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. | Putative Glutathione synthetase; Citation: Gushima et al. (1984) Nucleic Acids Res. 12:9299-9307; Alternative locus ID: PMED4_01841. | 0.639 |
| gloB | pepA | PMM0559 | PMM1332 | Putative hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. | 0.661 |
| glyA | gshB | PMM0258 | PMM0178 | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative Glutathione synthetase; Citation: Gushima et al. (1984) Nucleic Acids Res. 12:9299-9307; Alternative locus ID: PMED4_01841. | 0.810 |
| glyA | metH | PMM0258 | PMM0877 | Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.968 |