STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BioAPutative diaminopelargonic acid synthase; Citation: Otsuka et al. (1988) J. Biol. Chem. 263:19577-19585; Kack et al. (1999) J. Mol. Biol. 291:857-876; Alternative locus ID: PMED4_16811; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (433 aa)    
Predicted Functional Partners:
bioF
Putative 8-amino-7-oxononanoate synthase; Citation: Otsuka et al. (1988) J. Biol. Chem. 263:19577-19585; Alexeev et al. (1998) J. Mol. Biol. 284:401-419; Alternative locus ID: PMED4_16771.
 
 0.999
BioD
Putative Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 0.999
BioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
 0.994
PMM1470
Conserved hypothetical protein; Possible SAM-dependent methyltransferase; Alternative locus ID: PMED4_16791.
 
  
 0.903
PMM1469
Conserved hypothetical; Alternative locus ID: PMED4_16781.
  
  
 0.839
BirA
Putative Biotin--acetyl-CoA-carboxylase ligase; Citation: Howard et al. (1985) Gene 35:321-331; Alternative locus ID: PMED4_04801.
  
  
 0.675
PMM1467
Putative DNA helicase; Alternative locus ID: PMED4_16761.
  
    0.647
accB,fabE
Biotin / Lipoyl attachment:Acetyl-CoA biotin carboxyl carrier subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
   
  
 0.536
PMM0917
Pyridoxal-dependent decarboxylase family protein; Alternative locus ID: PMED4_10281.
 
 
    0.520
nadE
Carbon-nitrogen hydrolase:NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.489
Your Current Organism:
Prochlorococcus marinus pastoris
NCBI taxonomy Id: 59919
Other names: P. marinus subsp. pastoris str. CCMP1986, Prochlorococcus marinus MED4, Prochlorococcus marinus subsp. pastoris str. CCMP1378, Prochlorococcus marinus subsp. pastoris str. CCMP1986, Prochlorococcus sp. CCMP1378, Prochlorococcus sp. MED4
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