| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AAZ57634.1 | AAZ59335.1 | PMN2A_0142 | PMN2A_1847 | Alanine-glyoxylate aminotransferase apoenzyme; Alternative locus ID: NATL2_07561. | Phosphoglycerate mutase; Alternative locus ID: NATL2_05541; Belongs to the phosphoglycerate mutase family. | 0.903 |
| AAZ57634.1 | glyA | PMN2A_0142 | PMN2A_1624 | Alanine-glyoxylate aminotransferase apoenzyme; Alternative locus ID: NATL2_07561. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.919 |
| AAZ57634.1 | ilvA | PMN2A_0142 | PMN2A_0299 | Alanine-glyoxylate aminotransferase apoenzyme; Alternative locus ID: NATL2_07561. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.914 |
| AAZ57634.1 | trpA | PMN2A_0142 | PMN2A_0008 | Alanine-glyoxylate aminotransferase apoenzyme; Alternative locus ID: NATL2_07561. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.902 |
| AAZ57634.1 | trpB | PMN2A_0142 | PMN2A_1531 | Alanine-glyoxylate aminotransferase apoenzyme; Alternative locus ID: NATL2_07561. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.901 |
| AAZ57825.1 | AAZ58816.1 | PMN2A_0333 | PMN2A_1327 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.544 |
| AAZ57825.1 | AAZ59335.1 | PMN2A_0333 | PMN2A_1847 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoglycerate mutase; Alternative locus ID: NATL2_05541; Belongs to the phosphoglycerate mutase family. | 0.424 |
| AAZ57825.1 | AAZ59346.1 | PMN2A_0333 | PMN2A_1858 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Acetolactate synthase, large subunit; Alternative locus ID: NATL2_05651. | 0.421 |
| AAZ57825.1 | glyA | PMN2A_0333 | PMN2A_1624 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.942 |
| AAZ57825.1 | ilvA | PMN2A_0333 | PMN2A_0299 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.905 |
| AAZ57825.1 | leuB | PMN2A_0333 | PMN2A_0194 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.407 |
| AAZ57825.1 | trpB | PMN2A_0333 | PMN2A_1531 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.405 |
| AAZ58255.1 | AAZ58816.1 | PMN2A_0764 | PMN2A_1327 | Acetolactate synthase, small subunit; Alternative locus ID: NATL2_15431. | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.582 |
| AAZ58255.1 | AAZ59346.1 | PMN2A_0764 | PMN2A_1858 | Acetolactate synthase, small subunit; Alternative locus ID: NATL2_15431. | Acetolactate synthase, large subunit; Alternative locus ID: NATL2_05651. | 0.999 |
| AAZ58255.1 | ilvA | PMN2A_0764 | PMN2A_0299 | Acetolactate synthase, small subunit; Alternative locus ID: NATL2_15431. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.972 |
| AAZ58255.1 | leuB | PMN2A_0764 | PMN2A_0194 | Acetolactate synthase, small subunit; Alternative locus ID: NATL2_15431. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.986 |
| AAZ58816.1 | AAZ57825.1 | PMN2A_1327 | PMN2A_0333 | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.544 |
| AAZ58816.1 | AAZ58255.1 | PMN2A_1327 | PMN2A_0764 | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Acetolactate synthase, small subunit; Alternative locus ID: NATL2_15431. | 0.582 |
| AAZ58816.1 | AAZ59346.1 | PMN2A_1327 | PMN2A_1858 | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Acetolactate synthase, large subunit; Alternative locus ID: NATL2_05651. | 0.512 |
| AAZ58816.1 | glyA | PMN2A_1327 | PMN2A_1624 | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.433 |
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