| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AAZ58156.1 | AAZ58777.1 | PMN2A_0665 | PMN2A_1287 | Orn/Lys/Arg decarboxylases family 1; Alternative locus ID: NATL2_14351. | Agmatinase; Alternative locus ID: NATL2_21141; Belongs to the arginase family. | 0.550 |
| AAZ58156.1 | speE | PMN2A_0665 | PMN2A_1286 | Orn/Lys/Arg decarboxylases family 1; Alternative locus ID: NATL2_14351. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.647 |
| AAZ58774.1 | AAZ58775.1 | PMN2A_1284 | PMN2A_1285 | Possible AIR synthase related protein, C-termi; Alternative locus ID: NATL2_21111. | MazG; Alternative locus ID: NATL2_21121. | 0.573 |
| AAZ58774.1 | AAZ58777.1 | PMN2A_1284 | PMN2A_1287 | Possible AIR synthase related protein, C-termi; Alternative locus ID: NATL2_21111. | Agmatinase; Alternative locus ID: NATL2_21141; Belongs to the arginase family. | 0.567 |
| AAZ58774.1 | speE | PMN2A_1284 | PMN2A_1286 | Possible AIR synthase related protein, C-termi; Alternative locus ID: NATL2_21111. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.566 |
| AAZ58775.1 | AAZ58774.1 | PMN2A_1285 | PMN2A_1284 | MazG; Alternative locus ID: NATL2_21121. | Possible AIR synthase related protein, C-termi; Alternative locus ID: NATL2_21111. | 0.573 |
| AAZ58775.1 | AAZ58777.1 | PMN2A_1285 | PMN2A_1287 | MazG; Alternative locus ID: NATL2_21121. | Agmatinase; Alternative locus ID: NATL2_21141; Belongs to the arginase family. | 0.803 |
| AAZ58775.1 | speE | PMN2A_1285 | PMN2A_1286 | MazG; Alternative locus ID: NATL2_21121. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.803 |
| AAZ58777.1 | AAZ58156.1 | PMN2A_1287 | PMN2A_0665 | Agmatinase; Alternative locus ID: NATL2_21141; Belongs to the arginase family. | Orn/Lys/Arg decarboxylases family 1; Alternative locus ID: NATL2_14351. | 0.550 |
| AAZ58777.1 | AAZ58774.1 | PMN2A_1287 | PMN2A_1284 | Agmatinase; Alternative locus ID: NATL2_21141; Belongs to the arginase family. | Possible AIR synthase related protein, C-termi; Alternative locus ID: NATL2_21111. | 0.567 |
| AAZ58777.1 | AAZ58775.1 | PMN2A_1287 | PMN2A_1285 | Agmatinase; Alternative locus ID: NATL2_21141; Belongs to the arginase family. | MazG; Alternative locus ID: NATL2_21121. | 0.803 |
| AAZ58777.1 | speE | PMN2A_1287 | PMN2A_1286 | Agmatinase; Alternative locus ID: NATL2_21141; Belongs to the arginase family. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.991 |
| lysA | speE | PMN2A_0658 | PMN2A_1286 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.408 |
| metK | nnrE | PMN2A_1687 | PMN2A_0857 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Protein of unknown function UPF0031:YjeF-related protein, N-terminal protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD [...] | 0.600 |
| metK | pyrG | PMN2A_1687 | PMN2A_1291 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.524 |
| metK | speE | PMN2A_1687 | PMN2A_1286 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.457 |
| metK | speH | PMN2A_1687 | PMN2A_1144 | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. | 0.934 |
| mtnP | speE | PMN2A_1666 | PMN2A_1286 | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.949 |
| nnrE | metK | PMN2A_0857 | PMN2A_1687 | Protein of unknown function UPF0031:YjeF-related protein, N-terminal protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD [...] | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.600 |
| nnrE | speE | PMN2A_0857 | PMN2A_1286 | Protein of unknown function UPF0031:YjeF-related protein, N-terminal protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD [...] | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.463 |