close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AAZ58786.1uroporphyrinogen-III C-methyltransferase; Alternative locus ID: NATL2_21231. (261 aa)    
Predicted Functional Partners:
AAZ58970.1
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 0.995
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 0.976
AAZ58788.1
Assimilatory nitrite reductase (ferredoxin) precursor; Alternative locus ID: NATL2_21261; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.936
AAZ59211.1
Cobalt-factor II C20-methyltransferase / precorrin-2 C20-methyltransferase; Alternative locus ID: NATL2_04231; Belongs to the precorrin methyltransferase family.
 
 
 0.934
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.932
AAZ58933.1
Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.896
AAZ58787.1
Possible DNA mismatch repair proteins, mutS fa; Alternative locus ID: NATL2_21241.
  
  
 0.879
AAZ57654.1
Sulfite reductase (ferredoxin); Alternative locus ID: NATL2_07761; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.862
AAZ59071.1
Porphobilinogen synthase; Alternative locus ID: NATL2_02731; Belongs to the ALAD family.
 
  
 0.735
cysC
Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate.
  
  
 0.703
Your Current Organism:
Prochlorococcus marinus NATL2A
NCBI taxonomy Id: 59920
Other names: P. marinus str. NATL2A, Prochlorococcus marinus str. NATL2A, Prochlorococcus sp. NATL2A
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.