node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAZ57773.1 | AAZ57787.1 | PMN2A_0281 | PMN2A_0295 | Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Pyruvate kinase; Alternative locus ID: NATL2_09131; Belongs to the pyruvate kinase family. | 0.948 |
AAZ57773.1 | AAZ58255.1 | PMN2A_0281 | PMN2A_0764 | Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Acetolactate synthase, small subunit; Alternative locus ID: NATL2_15431. | 0.836 |
AAZ57773.1 | AAZ59109.1 | PMN2A_0281 | PMN2A_1621 | Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 3-isopropylmalate dehydratase, small subunit; Alternative locus ID: NATL2_03131; Belongs to the LeuD family. | 0.800 |
AAZ57773.1 | leuA | PMN2A_0281 | PMN2A_0686 | Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.838 |
AAZ57773.1 | leuB | PMN2A_0281 | PMN2A_0194 | Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.451 |
AAZ57773.1 | leuC | PMN2A_0281 | PMN2A_1622 | Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.800 |
AAZ57773.1 | pdhA | PMN2A_0281 | PMN2A_0855 | Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Pyruvate dehydrogenase (lipoamide); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.999 |
AAZ57787.1 | AAZ57773.1 | PMN2A_0295 | PMN2A_0281 | Pyruvate kinase; Alternative locus ID: NATL2_09131; Belongs to the pyruvate kinase family. | Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.948 |
AAZ57787.1 | AAZ58255.1 | PMN2A_0295 | PMN2A_0764 | Pyruvate kinase; Alternative locus ID: NATL2_09131; Belongs to the pyruvate kinase family. | Acetolactate synthase, small subunit; Alternative locus ID: NATL2_15431. | 0.800 |
AAZ57787.1 | AAZ59109.1 | PMN2A_0295 | PMN2A_1621 | Pyruvate kinase; Alternative locus ID: NATL2_09131; Belongs to the pyruvate kinase family. | 3-isopropylmalate dehydratase, small subunit; Alternative locus ID: NATL2_03131; Belongs to the LeuD family. | 0.871 |
AAZ57787.1 | ilvD | PMN2A_0295 | PMN2A_0180 | Pyruvate kinase; Alternative locus ID: NATL2_09131; Belongs to the pyruvate kinase family. | Dihydroxyacid dehydratase; Alternative locus ID: NATL2_07941; Belongs to the IlvD/Edd family. | 0.532 |
AAZ57787.1 | leuA | PMN2A_0295 | PMN2A_0686 | Pyruvate kinase; Alternative locus ID: NATL2_09131; Belongs to the pyruvate kinase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.832 |
AAZ57787.1 | leuC | PMN2A_0295 | PMN2A_1622 | Pyruvate kinase; Alternative locus ID: NATL2_09131; Belongs to the pyruvate kinase family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.813 |
AAZ57787.1 | pdhA | PMN2A_0295 | PMN2A_0855 | Pyruvate kinase; Alternative locus ID: NATL2_09131; Belongs to the pyruvate kinase family. | Pyruvate dehydrogenase (lipoamide); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.947 |
AAZ58255.1 | AAZ57773.1 | PMN2A_0764 | PMN2A_0281 | Acetolactate synthase, small subunit; Alternative locus ID: NATL2_15431. | Pyruvate dehydrogenase E1 beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.836 |
AAZ58255.1 | AAZ57787.1 | PMN2A_0764 | PMN2A_0295 | Acetolactate synthase, small subunit; Alternative locus ID: NATL2_15431. | Pyruvate kinase; Alternative locus ID: NATL2_09131; Belongs to the pyruvate kinase family. | 0.800 |
AAZ58255.1 | AAZ59109.1 | PMN2A_0764 | PMN2A_1621 | Acetolactate synthase, small subunit; Alternative locus ID: NATL2_15431. | 3-isopropylmalate dehydratase, small subunit; Alternative locus ID: NATL2_03131; Belongs to the LeuD family. | 0.845 |
AAZ58255.1 | ilvC | PMN2A_0764 | PMN2A_0881 | Acetolactate synthase, small subunit; Alternative locus ID: NATL2_15431. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.996 |
AAZ58255.1 | ilvD | PMN2A_0764 | PMN2A_0180 | Acetolactate synthase, small subunit; Alternative locus ID: NATL2_15431. | Dihydroxyacid dehydratase; Alternative locus ID: NATL2_07941; Belongs to the IlvD/Edd family. | 0.767 |
AAZ58255.1 | leuA | PMN2A_0764 | PMN2A_0686 | Acetolactate synthase, small subunit; Alternative locus ID: NATL2_15431. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.947 |