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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (968 aa)    
Predicted Functional Partners:
AAZ59260.1
Conserved hypothetical protein; Alternative locus ID: NATL2_04771.
     
 0.860
AAZ59257.1
Conserved hypothetical protein; Alternative locus ID: NATL2_04741.
       0.850
AAZ59258.1
Uncharacterized conserved membrane protein; Alternative locus ID: NATL2_04751.
       0.850
AAZ59259.1
Protein of unknown function DUF102; Alternative locus ID: NATL2_04761; Belongs to the UPF0284 family.
       0.850
AAZ57605.1
Phosphoesterase; Alternative locus ID: NATL2_07201.
 
 0.830
polA
DNA polymerase A; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.824
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
 0.766
AAZ58568.1
Glutamate synthase (ferredoxin); Alternative locus ID: NATL2_18951.
  
  
 0.752
AAZ58690.1
Single-strand binding protein; Alternative locus ID: NATL2_20221.
  
 
 0.699
AAZ59323.1
Single-stranded DNA-binding protein; Alternative locus ID: NATL2_05421.
  
 
 0.699
Your Current Organism:
Prochlorococcus marinus NATL2A
NCBI taxonomy Id: 59920
Other names: P. marinus str. NATL2A, Prochlorococcus marinus str. NATL2A, Prochlorococcus sp. NATL2A
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