STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folCPutuative bifunctional Dihydrofolate/Folylpolyglutamate synthase; COG285 Folylpolyglutamate synthase [Coenzyme metabolism]; Belongs to the folylpolyglutamate synthase family. (413 aa)    
Predicted Functional Partners:
argD
COG4992 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
     
 0.821
glyA
Serine hydroxymethyltransferase (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.736
guaA
Glutamine amidotransferase class-I:GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
  
 0.720
ABM78728.1
COG1357 Uncharacterized low-complexity proteins [Function unknown].
       0.709
ABM78139.1
Hypothetical protein.
  
  
 0.657
folE
COG302 GTP cyclohydrolase I [Coenzyme metabolism].
  
  
 0.643
folB
COG1539 Dihydroneopterin aldolase [Coenzyme metabolism].
  
  
 0.643
folK
Possible 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; COG801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism].
  
  
 0.643
panC
Panthothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.
  
  
 0.573
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
   
 0.557
Your Current Organism:
Prochlorococcus marinus MIT9303
NCBI taxonomy Id: 59922
Other names: P. marinus str. MIT 9303, Prochlorococcus marinus str. MIT 9303, Prochlorococcus sp. MIT 9303, Prochlorococcus sp. MIT9303
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.