STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EU91_0445Folate-dependent protein for Fe/S cluster synthesis/repair in oxidative stress; Alternative locus ID: PGP2_0767. (278 aa)    
Predicted Functional Partners:
EU91_1833
Glycine dehydrogenase (decarboxylating) (glycine cleavage system P protein); Alternative locus ID: PGP2_0435; Belongs to the GcvP family.
     
 0.854
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
       0.812
gcvT
Aminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine.
     
 0.649
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.647
EU91_0443
CBS-domain containing hemolysin; Alternative locus ID: PGP2_0765.
 
     0.623
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
     
 0.614
EU91_1536
Hypothetical protein; Alternative locus ID: PGP2_0137; FIG00940966: hypothetical protein.
  
     0.610
folD
Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
     
 0.597
EU91_0084
Alternative locus ID: PGP2_1433; Protein of unknown function DUF490.
  
     0.503
EU91_0287
Putative iron binding protein from the HesB_IscA_SufA family; Alternative locus ID: PGP2_0609; Belongs to the HesB/IscA family.
   
 
 0.489
Your Current Organism:
Prochlorococcus marinus GP2
NCBI taxonomy Id: 59925
Other names: P. marinus str. GP2, Prochlorococcus marinus str. GP2, Prochlorococcus marinus str. RCC296, Prochlorococcus sp. GP2, Prochlorococcus sp. RCC296
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.