STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (217 aa)    
Predicted Functional Partners:
EV02_0712
Exodeoxyribonuclease III; Alternative locus ID: PSB_0180.
 
 0.992
EV02_0157
NAD dependent epimerase/dehydratase; Alternative locus ID: PSB_1554.
   
   0.749
polA
DNA polymerasee I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.732
EV02_1387
GMP synthase (glutamine-hydrolyzing); Alternative locus ID: PSB_0856.
      0.718
mutM
Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
   
  
 0.694
EV02_0159
ABC transporter; Alternative locus ID: PSB_1556; ATP binding component, possibly iron transporter; Belongs to the ABC transporter superfamily.
       0.665
EV02_0156
Hypothetical protein; Alternative locus ID: PSB_1553; FIG00940552: hypothetical protein.
       0.610
EV02_0160
Ferritin; Iron-storage protein.
       0.459
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
   
 
  0.421
EV02_0682
Signal peptidase I; Alternative locus ID: PSB_0150; Belongs to the peptidase S26 family.
  
  
 0.408
Your Current Organism:
Prochlorococcus marinus SB
NCBI taxonomy Id: 59926
Other names: P. marinus str. SB, Prochlorococcus marinus str. RCC295, Prochlorococcus marinus str. SB, Prochlorococcus sp. RCC295, Prochlorococcus sp. SB
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.