STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
hisHImidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (205 aa)    
Predicted Functional Partners:
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Alternative locus ID: PSB_1549.
 
 
 0.999
hisI
Phosphoribosyl-AMP cyclohydrolase; Alternative locus ID: PSB_0086; Phosphoribosyl-ATP pyrophosphatasee; In the N-terminal section; belongs to the PRA-CH family.
 
 
 0.999
hisF
Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 0.999
hisB
Imidazoleglycerol-phosphate dehydratase; Alternative locus ID: PSB_0408.
 
 
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
 
 0.996
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
 
  
 0.989
EV02_1446
Ferredoxin-dependent glutamate synthase; Alternative locus ID: PSB_0915.
  
 
 0.954
EV02_1037
Histidinol-phosphate aminotransferase; Alternative locus ID: PSB_0505.
 
 
 0.926
purH
IMP cyclohydrolase; Alternative locus ID: PSB_0423; Phosphoribosylaminoimidazolecarboxamide formyltransferase.
    
 0.920
EV02_1025
L-threonine 3-O-phosphate decarboxylase; Alternative locus ID: PSB_0493.
 
 
 0.913
Your Current Organism:
Prochlorococcus marinus SB
NCBI taxonomy Id: 59926
Other names: P. marinus str. SB, Prochlorococcus marinus str. RCC295, Prochlorococcus marinus str. SB, Prochlorococcus sp. RCC295, Prochlorococcus sp. SB
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.