STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa)    
Predicted Functional Partners:
EV02_1285
Glycine dehydrogenase (decarboxylating) (glycine cleavage system P protein); Alternative locus ID: PSB_0753; Belongs to the GcvP family.
  
 
 0.999
gcvT
Aminomethyltransferase (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine.
 
 0.997
purH
IMP cyclohydrolase; Alternative locus ID: PSB_0423; Phosphoribosylaminoimidazolecarboxamide formyltransferase.
  
 0.996
folD
Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 0.975
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
 
 0.967
EV02_1446
Ferredoxin-dependent glutamate synthase; Alternative locus ID: PSB_0915.
    
 0.952
EV02_1071
5,10-methylenetetrahydrofolate reductase; Alternative locus ID: PSB_0539; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.947
EV02_0276
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
     
 0.946
EV02_1670
Dihydrofolate synthase; Alternative locus ID: PSB_1139; Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family.
  
 0.945
EV02_0979
Thymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
   
 0.937
Your Current Organism:
Prochlorococcus marinus SB
NCBI taxonomy Id: 59926
Other names: P. marinus str. SB, Prochlorococcus marinus str. RCC295, Prochlorococcus marinus str. SB, Prochlorococcus sp. RCC295, Prochlorococcus sp. SB
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