STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gyrBDNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (655 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 0.998
EAR17737.1
DNA gyrase/topoisomerase IV, subunit A; COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit.
 
 0.997
smc
Putative chromosome segregation protein, SMC ATPase superfamily protein; Required for chromosome condensation and partitioning. Belongs to the SMC family.
  
 
 0.891
EAR18969.1
Hypothetical protein; COG0514 Superfamily II DNA helicase.
  
 
 0.862
EAR17657.1
Putative ATP-dependent helicase; COG0553 Superfamily II DNA/RNA helicases, SNF2 family.
  
 
 0.861
EAR18595.1
Hypothetical protein; COG1357 Uncharacterized low-complexity proteins.
    
 
 0.794
EAR18828.1
Hypothetical protein; COG1357 Uncharacterized low-complexity proteins.
    
 
 0.794
EAR18175.1
Hypothetical protein; COG1226 Kef-type K+ transport systems, predicted NAD-binding component.
    
 
 0.794
EAR18255.1
Hypothetical protein; COG1357 Uncharacterized low-complexity proteins.
    
 
 0.794
EAR19012.1
Hypothetical protein; COG1357 Uncharacterized low-complexity proteins.
    
 
 0.794
Your Current Organism:
Synechococcus sp. WH 7805
NCBI taxonomy Id: 59931
Other names: S. sp. WH 7805, Synechococcus WH7805, Synechococcus sp. (strain WH7805), Synechococcus sp. WH7805
Server load: medium (72%) [HD]