| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAR17657.1 | EAR18969.1 | WH7805_01045 | WH7805_06426 | Putative ATP-dependent helicase; COG0553 Superfamily II DNA/RNA helicases, SNF2 family. | Hypothetical protein; COG0514 Superfamily II DNA helicase. | 0.951 |
| EAR17657.1 | gyrB | WH7805_01045 | WH7805_08897 | Putative ATP-dependent helicase; COG0553 Superfamily II DNA/RNA helicases, SNF2 family. | DNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.861 |
| EAR17657.1 | smc | WH7805_01045 | WH7805_11803 | Putative ATP-dependent helicase; COG0553 Superfamily II DNA/RNA helicases, SNF2 family. | Putative chromosome segregation protein, SMC ATPase superfamily protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 0.612 |
| EAR17737.1 | gyrB | WH7805_09414 | WH7805_08897 | DNA gyrase/topoisomerase IV, subunit A; COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit. | DNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.997 |
| EAR17737.1 | smc | WH7805_09414 | WH7805_11803 | DNA gyrase/topoisomerase IV, subunit A; COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit. | Putative chromosome segregation protein, SMC ATPase superfamily protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 0.449 |
| EAR18175.1 | gyrB | WH7805_05266 | WH7805_08897 | Hypothetical protein; COG1226 Kef-type K+ transport systems, predicted NAD-binding component. | DNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.794 |
| EAR18255.1 | gyrB | WH7805_05666 | WH7805_08897 | Hypothetical protein; COG1357 Uncharacterized low-complexity proteins. | DNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.794 |
| EAR18595.1 | EAR19012.1 | WH7805_02132 | WH7805_06641 | Hypothetical protein; COG1357 Uncharacterized low-complexity proteins. | Hypothetical protein; COG1357 Uncharacterized low-complexity proteins. | 0.770 |
| EAR18595.1 | gyrB | WH7805_02132 | WH7805_08897 | Hypothetical protein; COG1357 Uncharacterized low-complexity proteins. | DNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.794 |
| EAR18828.1 | EAR19012.1 | WH7805_03297 | WH7805_06641 | Hypothetical protein; COG1357 Uncharacterized low-complexity proteins. | Hypothetical protein; COG1357 Uncharacterized low-complexity proteins. | 0.764 |
| EAR18828.1 | gyrB | WH7805_03297 | WH7805_08897 | Hypothetical protein; COG1357 Uncharacterized low-complexity proteins. | DNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.794 |
| EAR18969.1 | EAR17657.1 | WH7805_06426 | WH7805_01045 | Hypothetical protein; COG0514 Superfamily II DNA helicase. | Putative ATP-dependent helicase; COG0553 Superfamily II DNA/RNA helicases, SNF2 family. | 0.951 |
| EAR18969.1 | gyrB | WH7805_06426 | WH7805_08897 | Hypothetical protein; COG0514 Superfamily II DNA helicase. | DNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.862 |
| EAR18969.1 | smc | WH7805_06426 | WH7805_11803 | Hypothetical protein; COG0514 Superfamily II DNA helicase. | Putative chromosome segregation protein, SMC ATPase superfamily protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 0.830 |
| EAR19012.1 | EAR18595.1 | WH7805_06641 | WH7805_02132 | Hypothetical protein; COG1357 Uncharacterized low-complexity proteins. | Hypothetical protein; COG1357 Uncharacterized low-complexity proteins. | 0.770 |
| EAR19012.1 | EAR18828.1 | WH7805_06641 | WH7805_03297 | Hypothetical protein; COG1357 Uncharacterized low-complexity proteins. | Hypothetical protein; COG1357 Uncharacterized low-complexity proteins. | 0.764 |
| EAR19012.1 | gyrB | WH7805_06641 | WH7805_08897 | Hypothetical protein; COG1357 Uncharacterized low-complexity proteins. | DNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.794 |
| gyrA | gyrB | WH7805_04756 | WH7805_08897 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.998 |
| gyrB | EAR17657.1 | WH7805_08897 | WH7805_01045 | DNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Putative ATP-dependent helicase; COG0553 Superfamily II DNA/RNA helicases, SNF2 family. | 0.861 |
| gyrB | EAR17737.1 | WH7805_08897 | WH7805_09414 | DNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA gyrase/topoisomerase IV, subunit A; COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit. | 0.997 |