| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cysS | folE | BPLAN_071 | BPLAN_070 | COG0215; Protein involved in cysteinyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. | GTP cyclohydrolase I; COG0302; Protein involved in tetrahydrofolate biosynthetic process. | 0.821 |
| cysS | nadE | BPLAN_071 | BPLAN_069 | COG0215; Protein involved in cysteinyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. | NH(3)-dependent NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.561 |
| cysS | ribD | BPLAN_071 | BPLAN_491 | COG0215; Protein involved in cysteinyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.550 |
| dnaK | folE | BPLAN_410 | BPLAN_070 | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | GTP cyclohydrolase I; COG0302; Protein involved in tetrahydrofolate biosynthetic process. | 0.558 |
| dnaK | folP | BPLAN_410 | BPLAN_533 | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.534 |
| dnaK | hflB | BPLAN_410 | BPLAN_413 | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | AAA-metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.574 |
| dnaK | ndk | BPLAN_410 | BPLAN_187 | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Nucleoside-diphosphate kinase; COG0105. | 0.520 |
| folB | folE | BPLAN_348 | BPLAN_070 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase I; COG0302; Protein involved in tetrahydrofolate biosynthetic process. | 0.932 |
| folB | folK | BPLAN_348 | BPLAN_016 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine; COG0801. | 0.970 |
| folB | folP | BPLAN_348 | BPLAN_533 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.992 |
| folB | hflB | BPLAN_348 | BPLAN_413 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | AAA-metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.402 |
| folB | ribD | BPLAN_348 | BPLAN_491 | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.625 |
| folE | cysS | BPLAN_070 | BPLAN_071 | GTP cyclohydrolase I; COG0302; Protein involved in tetrahydrofolate biosynthetic process. | COG0215; Protein involved in cysteinyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.821 |
| folE | dnaK | BPLAN_070 | BPLAN_410 | GTP cyclohydrolase I; COG0302; Protein involved in tetrahydrofolate biosynthetic process. | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.558 |
| folE | folB | BPLAN_070 | BPLAN_348 | GTP cyclohydrolase I; COG0302; Protein involved in tetrahydrofolate biosynthetic process. | Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.932 |
| folE | folK | BPLAN_070 | BPLAN_016 | GTP cyclohydrolase I; COG0302; Protein involved in tetrahydrofolate biosynthetic process. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine; COG0801. | 0.932 |
| folE | folP | BPLAN_070 | BPLAN_533 | GTP cyclohydrolase I; COG0302; Protein involved in tetrahydrofolate biosynthetic process. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.932 |
| folE | hflB | BPLAN_070 | BPLAN_413 | GTP cyclohydrolase I; COG0302; Protein involved in tetrahydrofolate biosynthetic process. | AAA-metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.563 |
| folE | nadE | BPLAN_070 | BPLAN_069 | GTP cyclohydrolase I; COG0302; Protein involved in tetrahydrofolate biosynthetic process. | NH(3)-dependent NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.571 |
| folE | ndk | BPLAN_070 | BPLAN_187 | GTP cyclohydrolase I; COG0302; Protein involved in tetrahydrofolate biosynthetic process. | Nucleoside-diphosphate kinase; COG0105. | 0.835 |