| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| efp | ilvD | BPLAN_595 | BPLAN_083 | Elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | Dihydroxy-acid dehydratase; COG0129; Protein involved in valine biosynthetic process; Belongs to the IlvD/Edd family. | 0.742 |
| efp | thrA | BPLAN_595 | BPLAN_138 | Elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. | Aspartokinase/homoserine dehydrogenase; COG0527. | 0.739 |
| ilvA | ilvB | BPLAN_087 | BPLAN_084 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Putative acetolactate synthase large subunit; COG0028; Protein involved in valine biosynthetic process. | 0.965 |
| ilvA | ilvC | BPLAN_087 | BPLAN_086 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Ketol-acid reductoisomerase; COG0059; Protein involved in valine biosynthetic process. | 0.775 |
| ilvA | ilvD | BPLAN_087 | BPLAN_083 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Dihydroxy-acid dehydratase; COG0129; Protein involved in valine biosynthetic process; Belongs to the IlvD/Edd family. | 0.804 |
| ilvA | ilvE | BPLAN_087 | BPLAN_185 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | COG0115; Protein involved in branched chain family amino acid biosynthetic process. | 0.884 |
| ilvA | ilvH | BPLAN_087 | BPLAN_085 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase small subunit; COG0440. | 0.945 |
| ilvA | leuB | BPLAN_087 | BPLAN_564 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.926 |
| ilvA | thrA | BPLAN_087 | BPLAN_138 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Aspartokinase/homoserine dehydrogenase; COG0527. | 0.785 |
| ilvB | ilvA | BPLAN_084 | BPLAN_087 | Putative acetolactate synthase large subunit; COG0028; Protein involved in valine biosynthetic process. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.965 |
| ilvB | ilvC | BPLAN_084 | BPLAN_086 | Putative acetolactate synthase large subunit; COG0028; Protein involved in valine biosynthetic process. | Ketol-acid reductoisomerase; COG0059; Protein involved in valine biosynthetic process. | 0.990 |
| ilvB | ilvD | BPLAN_084 | BPLAN_083 | Putative acetolactate synthase large subunit; COG0028; Protein involved in valine biosynthetic process. | Dihydroxy-acid dehydratase; COG0129; Protein involved in valine biosynthetic process; Belongs to the IlvD/Edd family. | 0.990 |
| ilvB | ilvE | BPLAN_084 | BPLAN_185 | Putative acetolactate synthase large subunit; COG0028; Protein involved in valine biosynthetic process. | COG0115; Protein involved in branched chain family amino acid biosynthetic process. | 0.641 |
| ilvB | ilvH | BPLAN_084 | BPLAN_085 | Putative acetolactate synthase large subunit; COG0028; Protein involved in valine biosynthetic process. | Acetolactate synthase small subunit; COG0440. | 0.968 |
| ilvB | leuA | BPLAN_084 | BPLAN_567 | Putative acetolactate synthase large subunit; COG0028; Protein involved in valine biosynthetic process. | 2-isopropylmalate synthase; COG0119; Protein involved in leucine biosynthetic process; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.896 |
| ilvB | leuB | BPLAN_084 | BPLAN_564 | Putative acetolactate synthase large subunit; COG0028; Protein involved in valine biosynthetic process. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.945 |
| ilvB | leuC | BPLAN_084 | BPLAN_566 | Putative acetolactate synthase large subunit; COG0028; Protein involved in valine biosynthetic process. | 3-isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.452 |
| ilvB | thrA | BPLAN_084 | BPLAN_138 | Putative acetolactate synthase large subunit; COG0028; Protein involved in valine biosynthetic process. | Aspartokinase/homoserine dehydrogenase; COG0527. | 0.779 |
| ilvC | ilvA | BPLAN_086 | BPLAN_087 | Ketol-acid reductoisomerase; COG0059; Protein involved in valine biosynthetic process. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.775 |
| ilvC | ilvB | BPLAN_086 | BPLAN_084 | Ketol-acid reductoisomerase; COG0059; Protein involved in valine biosynthetic process. | Putative acetolactate synthase large subunit; COG0028; Protein involved in valine biosynthetic process. | 0.990 |