thyA protein (Blattabacterium sp. BPLAN) - STRING interaction network

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thyA

Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (279 aa)

Predicted Functional Partners:

folA

0.977

dut

0.960

gcvP

0.939

folD

0.934

gcvT

0.906

metF

0.905

surE

0.904

gcvH

0.902

lpdA

0.900

lpdA-2

0.900

Your Current Organism:

Blattabacterium sp. BPLAN

NCBI taxonomy Id: 600809
Other names: B. sp. (Periplaneta americana) str. BPLAN, Blattabacterium sp. (Periplaneta americana) str. BPLAN, Blattabacterium sp. (Periplaneta americana) strain BPLAN

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
dut	surE	BPLAN_035	BPLAN_149	Deoxyuridine 5'-triphosphate nucleotidohydrolase; COG0756.	Acid phosphatase, survival protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.905
dut	thyA	BPLAN_035	BPLAN_141	Deoxyuridine 5'-triphosphate nucleotidohydrolase; COG0756.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.960
folA	gcvP	BPLAN_191	BPLAN_025	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	COG1003; Protein involved in glycine decarboxylation via glycine cleavage system; Belongs to the GcvP family.	0.590
folA	gcvT	BPLAN_191	BPLAN_447	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	0.905
folA	thyA	BPLAN_191	BPLAN_141	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.977
folD	gcvH	BPLAN_198	BPLAN_223	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.946
folD	gcvP	BPLAN_198	BPLAN_025	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	COG1003; Protein involved in glycine decarboxylation via glycine cleavage system; Belongs to the GcvP family.	0.972
folD	gcvT	BPLAN_198	BPLAN_447	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	0.951
folD	lpdA	BPLAN_198	BPLAN_421	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	COG1249; Protein involved in dihydrolipoamide metabolic process.	0.907
folD	lpdA-2	BPLAN_198	BPLAN_486	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	COG1249; Protein involved in dihydrolipoamide metabolic process.	0.907
folD	metF	BPLAN_198	BPLAN_195	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	5,10-methylenetetrahydrofolate reductase; COG0685; Protein involved in methionine biosynthetic process; Belongs to the methylenetetrahydrofolate reductase family.	0.967
folD	thyA	BPLAN_198	BPLAN_141	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.934
gcvH	folD	BPLAN_223	BPLAN_198	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.946
gcvH	gcvP	BPLAN_223	BPLAN_025	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	COG1003; Protein involved in glycine decarboxylation via glycine cleavage system; Belongs to the GcvP family.	0.999
gcvH	gcvT	BPLAN_223	BPLAN_447	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	0.999
gcvH	lpdA	BPLAN_223	BPLAN_421	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	COG1249; Protein involved in dihydrolipoamide metabolic process.	0.961
gcvH	lpdA-2	BPLAN_223	BPLAN_486	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	COG1249; Protein involved in dihydrolipoamide metabolic process.	0.961
gcvH	metF	BPLAN_223	BPLAN_195	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	5,10-methylenetetrahydrofolate reductase; COG0685; Protein involved in methionine biosynthetic process; Belongs to the methylenetetrahydrofolate reductase family.	0.929
gcvH	thyA	BPLAN_223	BPLAN_141	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.902
gcvP	folA	BPLAN_025	BPLAN_191	COG1003; Protein involved in glycine decarboxylation via glycine cleavage system; Belongs to the GcvP family.	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	0.590

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