Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
trpFPhosphoribosylanthranilate isomerase PRAI/tryptophan synthase subunit beta; COG0135; Belongs to the TrpF family. (209 aa)    
Predicted Functional Partners:
trpA
Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
 0.999
trpB
Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
  
 0.999
trpC
Indole-3-glycerol phosphate synthase; COG0134; Belongs to the TrpC family.
 
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 
 0.999
trpE
COG0147; Protein involved in anthranilate synthase activity.
 
 
 0.998
trpG
Anthranilate synthase component II; COG0512; Protein involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor.
  
  
 0.995
hisI
Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; COG0139; Protein involved in phosphoribosyl-ATP diphosphatase activity; In the N-terminal section; belongs to the PRA-CH family.
  
  
 0.752
hisB
Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; COG0131; Protein involved in histidinol-phosphatase activity; Belongs to the imidazoleglycerol-phosphate dehydratase family. In the N-terminal section; belongs to the histidinol- phosphatase family.
  
  
 0.707
thrA
Aspartokinase/homoserine dehydrogenase; COG0527.
  
  
 0.674
pyrE
Bifunctional orotate phosphoribosyltransferase/orotidine 5'-phosphate decarboxylase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
  
 0.653
Your Current Organism:
Blattabacterium sp. BPLAN
NCBI taxonomy Id: 600809
Other names: B. sp. (Periplaneta americana) str. BPLAN, Blattabacterium sp. (Periplaneta americana) str. BPLAN, Blattabacterium sp. (Periplaneta americana) strain BPLAN
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