gcvH protein (Blattabacterium sp. BPLAN) - STRING interaction network

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gcvH

Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)

Predicted Functional Partners:

gcvP

0.999

gcvT

0.999

lpdA

0.961

lpdA-2

0.961

folD

0.946

metF

0.929

lipB

0.911

thyA

0.902

lipA

0.883

gdhA

0.812

Your Current Organism:

Blattabacterium sp. BPLAN

NCBI taxonomy Id: 600809
Other names: B. sp. (Periplaneta americana) str. BPLAN, Blattabacterium sp. (Periplaneta americana) str. BPLAN, Blattabacterium sp. (Periplaneta americana) strain BPLAN

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
folD	gcvH	BPLAN_198	BPLAN_223	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.946
folD	gcvP	BPLAN_198	BPLAN_025	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	COG1003; Protein involved in glycine decarboxylation via glycine cleavage system; Belongs to the GcvP family.	0.972
folD	gcvT	BPLAN_198	BPLAN_447	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	0.951
folD	lpdA	BPLAN_198	BPLAN_421	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	COG1249; Protein involved in dihydrolipoamide metabolic process.	0.907
folD	lpdA-2	BPLAN_198	BPLAN_486	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	COG1249; Protein involved in dihydrolipoamide metabolic process.	0.907
folD	metF	BPLAN_198	BPLAN_195	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	5,10-methylenetetrahydrofolate reductase; COG0685; Protein involved in methionine biosynthetic process; Belongs to the methylenetetrahydrofolate reductase family.	0.967
folD	thyA	BPLAN_198	BPLAN_141	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.934
gcvH	folD	BPLAN_223	BPLAN_198	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.946
gcvH	gcvP	BPLAN_223	BPLAN_025	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	COG1003; Protein involved in glycine decarboxylation via glycine cleavage system; Belongs to the GcvP family.	0.999
gcvH	gcvT	BPLAN_223	BPLAN_447	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	0.999
gcvH	gdhA	BPLAN_223	BPLAN_514	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Glutamate dehydrogenase; COG0334; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.812
gcvH	lipA	BPLAN_223	BPLAN_166	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.883
gcvH	lipB	BPLAN_223	BPLAN_289	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.	0.911
gcvH	lpdA	BPLAN_223	BPLAN_421	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	COG1249; Protein involved in dihydrolipoamide metabolic process.	0.961
gcvH	lpdA-2	BPLAN_223	BPLAN_486	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	COG1249; Protein involved in dihydrolipoamide metabolic process.	0.961
gcvH	metF	BPLAN_223	BPLAN_195	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	5,10-methylenetetrahydrofolate reductase; COG0685; Protein involved in methionine biosynthetic process; Belongs to the methylenetetrahydrofolate reductase family.	0.929
gcvH	thyA	BPLAN_223	BPLAN_141	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.902
gcvP	folD	BPLAN_025	BPLAN_198	COG1003; Protein involved in glycine decarboxylation via glycine cleavage system; Belongs to the GcvP family.	Putative methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.972
gcvP	gcvH	BPLAN_025	BPLAN_223	COG1003; Protein involved in glycine decarboxylation via glycine cleavage system; Belongs to the GcvP family.	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.999
gcvP	gcvT	BPLAN_025	BPLAN_447	COG1003; Protein involved in glycine decarboxylation via glycine cleavage system; Belongs to the GcvP family.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	0.999

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