metK protein (Blattabacterium sp. BPLAN) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

metK

S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (418 aa)

Predicted Functional Partners:

metE

0.967

ribE

0.927

purF

0.745

BPLAN_296

0.676

metF

0.672

hisI

0.665

tyrB

0.657

groL

0.656

fabI

0.636

rpe

0.635

Your Current Organism:

Blattabacterium sp. BPLAN

NCBI taxonomy Id: 600809
Other names: B. sp. (Periplaneta americana) str. BPLAN, Blattabacterium sp. (Periplaneta americana) str. BPLAN, Blattabacterium sp. (Periplaneta americana) strain BPLAN

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BPLAN_296	fabI	BPLAN_296	BPLAN_294	Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG)/chorismate mutase (pheA); COG2876; Protein involved in chorismate biosynthetic process.	Enoyl-[acyl-carrier-protein] reductase (NADH); COG0623.	0.545
BPLAN_296	metK	BPLAN_296	BPLAN_295	Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG)/chorismate mutase (pheA); COG2876; Protein involved in chorismate biosynthetic process.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.676
BPLAN_296	rpe	BPLAN_296	BPLAN_293	Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG)/chorismate mutase (pheA); COG2876; Protein involved in chorismate biosynthetic process.	Putative ribulose-phosphate 3-epimerase; COG0036; Protein involved in pentose-phosphate shunt; Belongs to the ribulose-phosphate 3-epimerase family.	0.475
BPLAN_296	tyrB	BPLAN_296	BPLAN_298	Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG)/chorismate mutase (pheA); COG2876; Protein involved in chorismate biosynthetic process.	Aspartate/tyrosine/aromatic aminotransferase; COG0436.	0.806
fabI	BPLAN_296	BPLAN_294	BPLAN_296	Enoyl-[acyl-carrier-protein] reductase (NADH); COG0623.	Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG)/chorismate mutase (pheA); COG2876; Protein involved in chorismate biosynthetic process.	0.545
fabI	metK	BPLAN_294	BPLAN_295	Enoyl-[acyl-carrier-protein] reductase (NADH); COG0623.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.636
fabI	rpe	BPLAN_294	BPLAN_293	Enoyl-[acyl-carrier-protein] reductase (NADH); COG0623.	Putative ribulose-phosphate 3-epimerase; COG0036; Protein involved in pentose-phosphate shunt; Belongs to the ribulose-phosphate 3-epimerase family.	0.594
fabI	tyrB	BPLAN_294	BPLAN_298	Enoyl-[acyl-carrier-protein] reductase (NADH); COG0623.	Aspartate/tyrosine/aromatic aminotransferase; COG0436.	0.475
groL	metK	BPLAN_434	BPLAN_295	60 kDa chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.656
hisI	metK	BPLAN_200	BPLAN_295	Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; COG0139; Protein involved in phosphoribosyl-ATP diphosphatase activity; In the N-terminal section; belongs to the PRA-CH family.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.665
hisI	purF	BPLAN_200	BPLAN_156	Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; COG0139; Protein involved in phosphoribosyl-ATP diphosphatase activity; In the N-terminal section; belongs to the PRA-CH family.	Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.	0.515
metE	metF	BPLAN_521	BPLAN_195	5-methyltetrahydropteroyltriglutamate-- homocysteine; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	5,10-methylenetetrahydrofolate reductase; COG0685; Protein involved in methionine biosynthetic process; Belongs to the methylenetetrahydrofolate reductase family.	0.832
metE	metK	BPLAN_521	BPLAN_295	5-methyltetrahydropteroyltriglutamate-- homocysteine; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.967
metF	metE	BPLAN_195	BPLAN_521	5,10-methylenetetrahydrofolate reductase; COG0685; Protein involved in methionine biosynthetic process; Belongs to the methylenetetrahydrofolate reductase family.	5-methyltetrahydropteroyltriglutamate-- homocysteine; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	0.832
metF	metK	BPLAN_195	BPLAN_295	5,10-methylenetetrahydrofolate reductase; COG0685; Protein involved in methionine biosynthetic process; Belongs to the methylenetetrahydrofolate reductase family.	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	0.672
metK	BPLAN_296	BPLAN_295	BPLAN_296	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	Phospho-2-dehydro-3-deoxyheptonate aldolase (aroG)/chorismate mutase (pheA); COG2876; Protein involved in chorismate biosynthetic process.	0.676
metK	fabI	BPLAN_295	BPLAN_294	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	Enoyl-[acyl-carrier-protein] reductase (NADH); COG0623.	0.636
metK	groL	BPLAN_295	BPLAN_434	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	60 kDa chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.656
metK	hisI	BPLAN_295	BPLAN_200	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; COG0139; Protein involved in phosphoribosyl-ATP diphosphatase activity; In the N-terminal section; belongs to the PRA-CH family.	0.665
metK	metE	BPLAN_295	BPLAN_521	S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.	5-methyltetrahydropteroyltriglutamate-- homocysteine; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.	0.967

page 1 of 2

Server load: low (12%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Co-occurrence

Textmining

Co-expression

© STRING Consortium 2026

Credits

Access

Info

About