| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BPLAN_068 | birA | BPLAN_068 | BPLAN_415 | Peptidase M22, glycoprotease; COG1214. | biotin-(acetyl-CoA carboxylase) ligase; COG0340; Protein involved in protein modification process. | 0.673 |
| accC | birA | BPLAN_123 | BPLAN_415 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | biotin-(acetyl-CoA carboxylase) ligase; COG0340; Protein involved in protein modification process. | 0.817 |
| accC | ribD | BPLAN_123 | BPLAN_491 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.851 |
| birA | BPLAN_068 | BPLAN_415 | BPLAN_068 | biotin-(acetyl-CoA carboxylase) ligase; COG0340; Protein involved in protein modification process. | Peptidase M22, glycoprotease; COG1214. | 0.673 |
| birA | accC | BPLAN_415 | BPLAN_123 | biotin-(acetyl-CoA carboxylase) ligase; COG0340; Protein involved in protein modification process. | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.817 |
| birA | cdsA | BPLAN_415 | BPLAN_412 | biotin-(acetyl-CoA carboxylase) ligase; COG0340; Protein involved in protein modification process. | Phosphatidate cytidylyltransferase; COG0575. | 0.571 |
| birA | guaB | BPLAN_415 | BPLAN_474 | biotin-(acetyl-CoA carboxylase) ligase; COG0340; Protein involved in protein modification process. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.440 |
| birA | hflB | BPLAN_415 | BPLAN_413 | biotin-(acetyl-CoA carboxylase) ligase; COG0340; Protein involved in protein modification process. | AAA-metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.553 |
| birA | lpxC | BPLAN_415 | BPLAN_596 | biotin-(acetyl-CoA carboxylase) ligase; COG0340; Protein involved in protein modification process. | UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. | 0.529 |
| birA | psd | BPLAN_415 | BPLAN_411 | biotin-(acetyl-CoA carboxylase) ligase; COG0340; Protein involved in protein modification process. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.484 |
| birA | ribD | BPLAN_415 | BPLAN_491 | biotin-(acetyl-CoA carboxylase) ligase; COG0340; Protein involved in protein modification process. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.515 |
| birA | rsfS | BPLAN_415 | BPLAN_414 | biotin-(acetyl-CoA carboxylase) ligase; COG0340; Protein involved in protein modification process. | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.616 |
| birA | tadA | BPLAN_415 | BPLAN_144 | biotin-(acetyl-CoA carboxylase) ligase; COG0340; Protein involved in protein modification process. | Putative cytosine/adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.639 |
| cdsA | birA | BPLAN_412 | BPLAN_415 | Phosphatidate cytidylyltransferase; COG0575. | biotin-(acetyl-CoA carboxylase) ligase; COG0340; Protein involved in protein modification process. | 0.571 |
| cdsA | hflB | BPLAN_412 | BPLAN_413 | Phosphatidate cytidylyltransferase; COG0575. | AAA-metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.712 |
| cdsA | psd | BPLAN_412 | BPLAN_411 | Phosphatidate cytidylyltransferase; COG0575. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.846 |
| cdsA | rsfS | BPLAN_412 | BPLAN_414 | Phosphatidate cytidylyltransferase; COG0575. | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.631 |
| guaB | birA | BPLAN_474 | BPLAN_415 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | biotin-(acetyl-CoA carboxylase) ligase; COG0340; Protein involved in protein modification process. | 0.440 |
| guaB | lpxC | BPLAN_474 | BPLAN_596 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. | 0.580 |
| guaB | ribD | BPLAN_474 | BPLAN_491 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.708 |