| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| folE | queE | BPLAN_070 | BPLAN_199 | GTP cyclohydrolase I; COG0302; Protein involved in tetrahydrofolate biosynthetic process. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.459 |
| folE | sscR | BPLAN_070 | BPLAN_446 | GTP cyclohydrolase I; COG0302; Protein involved in tetrahydrofolate biosynthetic process. | 6-pyruvoyl tetrahydrobiopterin synthase; COG0720. | 0.966 |
| gcvT | idi | BPLAN_447 | BPLAN_445 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Putative isopentenyl-diphosphate delta-isomerase; COG1443. | 0.744 |
| gcvT | mdtK | BPLAN_447 | BPLAN_448 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | NorM-like multidrug efflux protein; COG0534; Protein involved in response to drug. | 0.481 |
| gcvT | sscR | BPLAN_447 | BPLAN_446 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 6-pyruvoyl tetrahydrobiopterin synthase; COG0720. | 0.781 |
| guaA | queE | BPLAN_161 | BPLAN_199 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.538 |
| guaA | sscR | BPLAN_161 | BPLAN_446 | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | 6-pyruvoyl tetrahydrobiopterin synthase; COG0720. | 0.424 |
| hisI | sscR | BPLAN_200 | BPLAN_446 | Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; COG0139; Protein involved in phosphoribosyl-ATP diphosphatase activity; In the N-terminal section; belongs to the PRA-CH family. | 6-pyruvoyl tetrahydrobiopterin synthase; COG0720. | 0.540 |
| idi | gcvT | BPLAN_445 | BPLAN_447 | Putative isopentenyl-diphosphate delta-isomerase; COG1443. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.744 |
| idi | mdtK | BPLAN_445 | BPLAN_448 | Putative isopentenyl-diphosphate delta-isomerase; COG1443. | NorM-like multidrug efflux protein; COG0534; Protein involved in response to drug. | 0.451 |
| idi | sscR | BPLAN_445 | BPLAN_446 | Putative isopentenyl-diphosphate delta-isomerase; COG1443. | 6-pyruvoyl tetrahydrobiopterin synthase; COG0720. | 0.756 |
| mdtK | gcvT | BPLAN_448 | BPLAN_447 | NorM-like multidrug efflux protein; COG0534; Protein involved in response to drug. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.481 |
| mdtK | idi | BPLAN_448 | BPLAN_445 | NorM-like multidrug efflux protein; COG0534; Protein involved in response to drug. | Putative isopentenyl-diphosphate delta-isomerase; COG1443. | 0.451 |
| mdtK | sscR | BPLAN_448 | BPLAN_446 | NorM-like multidrug efflux protein; COG0534; Protein involved in response to drug. | 6-pyruvoyl tetrahydrobiopterin synthase; COG0720. | 0.481 |
| queE | folE | BPLAN_199 | BPLAN_070 | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | GTP cyclohydrolase I; COG0302; Protein involved in tetrahydrofolate biosynthetic process. | 0.459 |
| queE | guaA | BPLAN_199 | BPLAN_161 | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | 0.538 |
| queE | sscR | BPLAN_199 | BPLAN_446 | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 6-pyruvoyl tetrahydrobiopterin synthase; COG0720. | 0.987 |
| sscR | folE | BPLAN_446 | BPLAN_070 | 6-pyruvoyl tetrahydrobiopterin synthase; COG0720. | GTP cyclohydrolase I; COG0302; Protein involved in tetrahydrofolate biosynthetic process. | 0.966 |
| sscR | gcvT | BPLAN_446 | BPLAN_447 | 6-pyruvoyl tetrahydrobiopterin synthase; COG0720. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.781 |
| sscR | guaA | BPLAN_446 | BPLAN_161 | 6-pyruvoyl tetrahydrobiopterin synthase; COG0720. | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. | 0.424 |