STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdhASuccinate dehydrogenase flavoprotein subunit; COG1053; Protein involved in anaerobic respiration. (677 aa)    
Predicted Functional Partners:
sdhB
Succinate dehydrogenase/fumarate reductase, iron-sulfur protein; COG0479.
 
 0.999
sdhC
Succinate dehydrogenase subunit C/fumarate reductase; COG2009.
 
 
 0.997
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
 
 0.977
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.972
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.971
sad
Succinate-semialdehyde dehydrogenase; COG1012; Protein involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor.
   
 0.939
kgd
2-oxoglutarate dehydrogenase, E1 component; COG0567.
  
 
 0.916
aspC
Aspartate aminotransferase; COG0436.
   
 
 0.811
argH
Argininosuccinate lyase; COG0165; Protein involved in arginine biosynthetic process via ornithine.
     
 0.808
BPLAN_489
4Fe-4S ferredoxin, iron-sulfur binding protein; COG1145.
  
 
 0.799
Your Current Organism:
Blattabacterium sp. BPLAN
NCBI taxonomy Id: 600809
Other names: B. sp. (Periplaneta americana) str. BPLAN, Blattabacterium sp. (Periplaneta americana) str. BPLAN, Blattabacterium sp. (Periplaneta americana) strain BPLAN
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