SDR66791.1 protein (Olsenella umbonata) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

SDR66791.1

Fe-S cluster assembly ATP-binding protein. (255 aa)

Predicted Functional Partners:

SDR66782.1

0.999

SDR66767.1

0.996

SDR66772.1

0.996

SDR66760.1

0.985

SDR66750.1

0.786

SDR86150.1

0.776

SDR65427.1

0.675

SDR92070.1

0.637

SDR64966.1

0.439

SDR65750.1

0.439

Your Current Organism:

Olsenella umbonata

NCBI taxonomy Id: 604330
Other names: CCUG 58604, DSM 22620, JCM 16156, O. umbonata, Olsenella sp. A2, Olsenella sp. lac15, Olsenella sp. lac16, Olsenella sp. lac31, Olsenella umbonata Kraatz et al. 2011, strain lac31

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDR64966.1	SDR66791.1	SAMN04489857_0142	SAMN04489857_0456	Transcriptional regulator, LacI family.	Fe-S cluster assembly ATP-binding protein.	0.439
SDR65427.1	SDR66767.1	SAMN04489857_0263	SAMN04489857_0453	NifU homolog involved in Fe-S cluster formation.	Cysteine desulfurase / selenocysteine lyase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.	0.885
SDR65427.1	SDR66772.1	SAMN04489857_0263	SAMN04489857_0454	NifU homolog involved in Fe-S cluster formation.	Uncharacterized protein family (UPF0051).	0.617
SDR65427.1	SDR66782.1	SAMN04489857_0263	SAMN04489857_0455	NifU homolog involved in Fe-S cluster formation.	Iron-regulated ABC transporter membrane component SufB.	0.617
SDR65427.1	SDR66791.1	SAMN04489857_0263	SAMN04489857_0456	NifU homolog involved in Fe-S cluster formation.	Fe-S cluster assembly ATP-binding protein.	0.675
SDR65427.1	SDR86150.1	SAMN04489857_0263	SAMN04489857_1436	NifU homolog involved in Fe-S cluster formation.	Cysteine desulfurase family protein.	0.885
SDR65427.1	SDR92070.1	SAMN04489857_0263	SAMN04489857_1633	NifU homolog involved in Fe-S cluster formation.	Xanthine dehydrogenase accessory factor.	0.885
SDR65750.1	SDR66791.1	SAMN04489857_0318	SAMN04489857_0456	Transcriptional regulator, LacI family.	Fe-S cluster assembly ATP-binding protein.	0.439
SDR66750.1	SDR66760.1	SAMN04489857_0451	SAMN04489857_0452	Rrf2 family protein.	Nitrogen fixation protein NifU.	0.858
SDR66750.1	SDR66767.1	SAMN04489857_0451	SAMN04489857_0453	Rrf2 family protein.	Cysteine desulfurase / selenocysteine lyase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.	0.777
SDR66750.1	SDR66772.1	SAMN04489857_0451	SAMN04489857_0454	Rrf2 family protein.	Uncharacterized protein family (UPF0051).	0.786
SDR66750.1	SDR66782.1	SAMN04489857_0451	SAMN04489857_0455	Rrf2 family protein.	Iron-regulated ABC transporter membrane component SufB.	0.784
SDR66750.1	SDR66791.1	SAMN04489857_0451	SAMN04489857_0456	Rrf2 family protein.	Fe-S cluster assembly ATP-binding protein.	0.786
SDR66760.1	SDR66750.1	SAMN04489857_0452	SAMN04489857_0451	Nitrogen fixation protein NifU.	Rrf2 family protein.	0.858
SDR66760.1	SDR66767.1	SAMN04489857_0452	SAMN04489857_0453	Nitrogen fixation protein NifU.	Cysteine desulfurase / selenocysteine lyase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.	0.997
SDR66760.1	SDR66772.1	SAMN04489857_0452	SAMN04489857_0454	Nitrogen fixation protein NifU.	Uncharacterized protein family (UPF0051).	0.979
SDR66760.1	SDR66782.1	SAMN04489857_0452	SAMN04489857_0455	Nitrogen fixation protein NifU.	Iron-regulated ABC transporter membrane component SufB.	0.979
SDR66760.1	SDR66791.1	SAMN04489857_0452	SAMN04489857_0456	Nitrogen fixation protein NifU.	Fe-S cluster assembly ATP-binding protein.	0.985
SDR66760.1	SDR86150.1	SAMN04489857_0452	SAMN04489857_1436	Nitrogen fixation protein NifU.	Cysteine desulfurase family protein.	0.923
SDR66760.1	SDR92070.1	SAMN04489857_0452	SAMN04489857_1633	Nitrogen fixation protein NifU.	Xanthine dehydrogenase accessory factor.	0.885

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Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.968

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006563

L-serine metabolic process

3 of 6

2.35

2.18

7.21e-05

GO:0008652

Cellular amino acid biosynthetic process

7 of 104

1.48

2.05

8.24e-07

GO:0009070

Serine family amino acid biosynthetic process

3 of 13

2.02

1.69

0.00044

GO:0000105

Histidine biosynthetic process

3 of 13

2.02

1.69

0.00044

GO:0006564

L-serine biosynthetic process

2 of 2

2.65

1.52

0.0017

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004636

phosphoribosyl-ATP diphosphatase activity

2 of 2

2.65

0.97

0.0175

GO:0004635

phosphoribosyl-AMP cyclohydrolase activity

2 of 2

2.65

0.97

0.0175

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1378

0.52

0.4

0.0029

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1258

Biosynthesis of amino acids

8 of 75

1.68

3.14

7.50e-10

CL:1260

Cysteine and methionine metabolism

5 of 28

1.91

2.62

1.56e-06

CL:1390

Histidine biosynthesis

3 of 5

2.43

2.13

9.98e-05

CL:1306

Serine biosynthesis, and Organic phosphonate metabolic process

3 of 5

2.43

2.13

9.98e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00260

Glycine, serine and threonine metabolism

7 of 46

1.84

3.69

2.11e-10

map01230

Biosynthesis of amino acids

10 of 141

1.51

3.02

6.73e-13

map00680

Methane metabolism

5 of 28

1.91

3.0

1.34e-07

map00270

Cysteine and methionine metabolism

5 of 39

1.76

2.6

4.86e-07

map00340

Histidine metabolism

3 of 24

1.75

1.6

0.00037

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0028

Amino-acid biosynthesis

6 of 54

1.7

2.59

2.14e-07

KW-0368

Histidine biosynthesis

3 of 10

2.13

1.87

0.00023

KW-0718

Serine biosynthesis

2 of 2

2.65

1.5

0.0018

KW-0032

Aminotransferase

2 of 17

1.73

0.73

0.0379

KW-0963

Cytoplasm

4 of 222

0.91

0.49

0.0433

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