Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TSIB_0089Predicted ATP-dependent protease; Contains an intein; Belongs to the peptidase S16 family. (1112 aa)    
Predicted Functional Partners:
ileS
Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
   
 
 0.851
rps2
30S ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family.
  
 0.836
TSIB_0088
Hypothetical protein.
       0.830
TSIB_1633
Malate dehydrogenase; Belongs to the LDH/MDH superfamily.
  
 0.823
TSIB_1678
RecJ-like exonuclease, containing OB-fold nucleic acid-binding domains.
 
 
 0.802
TSIB_1868
Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPN); Belongs to the aldehyde dehydrogenase family.
    
 0.789
TSIB_1518
NADH:ubiquinone oxidoreductase, NADH-binding subunit F.
  
 0.787
TSIB_1538
Thermosome beta subunit; Belongs to the TCP-1 chaperonin family.
  
 0.784
TSIB_1748
Thermosome alpha subunit; Belongs to the TCP-1 chaperonin family.
  
 0.784
TSIB_0799
3-hydroxy-3-methylglutaryl CoA synthase; Belongs to the thiolase-like superfamily. UPF0219 family.
  
  0.781
Your Current Organism:
Thermococcus sibiricus
NCBI taxonomy Id: 604354
Other names: T. sibiricus MM 739, Thermococcus sibiricus MM 739, Thermococcus sibiricus str. MM 739, Thermococcus sibiricus strain MM 739
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