Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
lysSLysyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (526 aa)    
Predicted Functional Partners:
TSIB_0118
Hypothetical protein.
       0.773
TSIB_0120
Indolepyruvate: ferredoxin oxidoreductase (IOR), subunit beta.
       0.700
TSIB_0116
Hypothetical protein.
       0.690
TSIB_0117
Hypothetical protein.
       0.690
spt5
NusG transcription antitermination protein; Stimulates transcription elongation; Belongs to the archaeal Spt5 family.
  
    0.680
metG
Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
     
 0.447
cmk
Cytidylate kinase.
  
     0.445
pyrH
Probable uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
 
     0.444
gltX
Glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
  
  
 0.439
TSIB_0121
Manganese-dependent transcription regulator.
       0.420
Your Current Organism:
Thermococcus sibiricus
NCBI taxonomy Id: 604354
Other names: T. sibiricus MM 739, Thermococcus sibiricus MM 739, Thermococcus sibiricus str. MM 739, Thermococcus sibiricus strain MM 739
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