Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TSIB_0470Competence damage-inducible protein A. (253 aa)    
Predicted Functional Partners:
TSIB_0488
Translation initiation factor eIF-2B, delta subunit; Belongs to the eIF-2B alpha/beta/delta subunits family.
       0.644
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
       0.644
TSIB_1230
Amino acid kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
       0.644
TSIB_1010
CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
  
  
 0.609
TSIB_1086
CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
  
  
 0.609
TSIB_0469
Predicted ATPase, PP-loop superfamily.
       0.577
gap
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
 
     0.572
TSIB_0468
N2, N2-dimethylguanosine tRNA methyltransferase.
       0.553
TSIB_1842
Sun/NOL1/NOP nucleolar protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
 
    0.485
TSIB_1222
Hypothetical protein; Belongs to the MEMO1 family.
       0.405
Your Current Organism:
Thermococcus sibiricus
NCBI taxonomy Id: 604354
Other names: T. sibiricus MM 739, Thermococcus sibiricus MM 739, Thermococcus sibiricus str. MM 739, Thermococcus sibiricus strain MM 739
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