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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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[Homology]
Score
TSIB_0577Predicted 3-isopropylmalate dehydratase. (261 aa)    
Predicted Functional Partners:
eif2a
Translation initiation factor 2 subunit alpha; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.
 
    0.906
nop10
Ribosome biogenesis protein Nop10; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
 
     0.898
rps27e
30S ribosomal protein S27e.
 
     0.893
rpl44e
50S ribosomal protein L44E; Binds to the 23S rRNA.
 
     0.879
TSIB_0578
Phosphohydrolase, PHP family.
       0.791
TSIB_1317
ABC-type cobalt transport system, CbiM permease component.
       0.644
TSIB_1320
ABC-type cobalt transport system, ATPase component; Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
       0.644
TSIB_1262
Predicted metalloprotease, containing Jab1/MPN domain.
  
     0.638
TSIB_0603
Predicted RNA-binding protein.
 
     0.621
polC
DNA polymerase II large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.
  
     0.621
Your Current Organism:
Thermococcus sibiricus
NCBI taxonomy Id: 604354
Other names: T. sibiricus MM 739, Thermococcus sibiricus MM 739, Thermococcus sibiricus str. MM 739, Thermococcus sibiricus strain MM 739
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