STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pxpALamB/YcsF family protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. (255 aa)    
Predicted Functional Partners:
TSIB_0729
Allophanate hydrolase, subunit 1.
  
 0.999
TSIB_0728
Allophanate hydrolase, subunit 2.
  
 0.993
TSIB_1110
Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
    
  0.807
TSIB_1761
Glutamine synthetase.
   
 
  0.806
purQ
Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
     
  0.800
TSIB_1465
Ferredoxin:NADP+ oxidoreductase, subunit alpha.
     
  0.800
TSIB_0432
Hypothetical protein.
 
    0.700
TSIB_0731
Hypothetical protein.
       0.651
TSIB_0232
Carbon starvation protein A.
  
    0.540
TSIB_1868
Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPN); Belongs to the aldehyde dehydrogenase family.
  
    0.539
Your Current Organism:
Thermococcus sibiricus
NCBI taxonomy Id: 604354
Other names: T. sibiricus MM 739, Thermococcus sibiricus MM 739, Thermococcus sibiricus str. MM 739, Thermococcus sibiricus strain MM 739
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.