Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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queEOrganic radical activating enzyme, radical SAM superfamily; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (251 aa)    
Predicted Functional Partners:
queC
Archaeosine biosynthesis protein queC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
 
 0.996
TSIB_0750
6-pyruvoyl-tetrahydropterin synthase-related protein.
 
 
 0.987
TSIB_0131
6-pyruvoyl tetrahydropterin synthase.
 
  
 0.886
TSIB_0865
Hypothetical protein.
       0.884
TSIB_0866
Hypothetical protein.
       0.884
tgtA
Archaeosine tRNA-guanine transglycosylase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
 
   
 0.597
TSIB_0864
Predicted transcription regulator, containing CBS domains.
       0.568
TSIB_0440
Orotidine 5'-phosphate decarboxylase.
     
 0.547
TSIB_0115
DUF366 domain containing protein.
 
     0.527
TSIB_0105
Probable molybdenum cofactor biosynthesis protein A.
     
 0.481
Your Current Organism:
Thermococcus sibiricus
NCBI taxonomy Id: 604354
Other names: T. sibiricus MM 739, Thermococcus sibiricus MM 739, Thermococcus sibiricus str. MM 739, Thermococcus sibiricus strain MM 739
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