Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
TSIB_0981Phosphoesterase, putative. (490 aa)    
Predicted Functional Partners:
TSIB_0982
Hypothetical protein.
       0.829
TSIB_0983
Permease, drug/metabolite transporter (DMT) superfamily.
 
    0.645
dacZ
Hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.
   
 0.610
TSIB_1358
DUF555 domain containing protein; Belongs to the UPF0212 family.
  
     0.563
TSIB_0084
Putative transcriptional regulatory protein.
  
     0.560
infB
Probable translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.
  
    0.456
TSIB_1842
Sun/NOL1/NOP nucleolar protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
  
 0.449
TSIB_1165
DUF460 multi-domain protein.
 
     0.427
TSIB_0725
Predicted membrane protein.
  
     0.417
TSIB_0780
Flagella accessory protein.
  
     0.415
Your Current Organism:
Thermococcus sibiricus
NCBI taxonomy Id: 604354
Other names: T. sibiricus MM 739, Thermococcus sibiricus MM 739, Thermococcus sibiricus str. MM 739, Thermococcus sibiricus strain MM 739
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