Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TSIB_1003Nucleotide-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (241 aa)    
Predicted Functional Partners:
hypA
Probable hydrogenase nickel incorporation protein hypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
   
   0.985
TSIB_1002
Hydrogenase maturation protease.
 
     0.895
TSIB_0698
Iron-molybdenum cofactor-binding protein.
 
  
 0.619
TSIB_1005
Glutamate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
 0.581
TSIB_1906
Membrane-bound NADP+-reducing complex MBX, subunit MbxL (dehydrogenase subunit); Belongs to the complex I 49 kDa subunit family.
    
 0.483
TSIB_1907
Membrane-bound NADP+-reducing complex MBX, subunit MbxK (dehydrogenase subunit).
    
 0.483
TSIB_1519
NADH:ubiquinone oxidoreductase, subunit E.
    
 0.470
TSIB_0502
FeoB ferrous iron transport protein B - like protein.
 
  
 0.468
TSIB_1027
Probable 2-methylthioadenine synthetase.
 
  
 0.453
TSIB_1908
Membrane-bound NADP+-reducing complex MBX, subunit MbxJ (dehydrogenase subunit).
     
 0.452
Your Current Organism:
Thermococcus sibiricus
NCBI taxonomy Id: 604354
Other names: T. sibiricus MM 739, Thermococcus sibiricus MM 739, Thermococcus sibiricus str. MM 739, Thermococcus sibiricus strain MM 739
Server load: low (16%) [HD]