STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TSIB_1016D-isomer specific 2-hydroxyacid dehydrogenase. (333 aa)    
Predicted Functional Partners:
TSIB_1605
Putative glycerate kinase.
 
 0.946
TSIB_0439
Phosphoglycolate phosphatase; Catalyzes the dephosphorylation of 2-phosphoglycolate.
  
 
 0.921
TSIB_1280
Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
  
 
0.907
proS
Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
  
 
 0.703
TSIB_0536
Peptidase U34, dipeptidase.
   
    0.528
TSIB_0471
Pyruvate kinase (PYK); Belongs to the pyruvate kinase family.
 
 
 0.493
TSIB_0773
Alkyldihydroxyacetonephosphate synthase.
 
 
 
 0.479
TSIB_0428
Bifunctional D-arabino 3-hexulose-6-phosphate formaldehyde lyase/phosphohexuloisomerase.
 
 
 
 0.459
TSIB_2019
Pyrophosphorylase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
 
 0.434
rpl4
50S ribosomal protein L4P; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
  
 
 0.423
Your Current Organism:
Thermococcus sibiricus
NCBI taxonomy Id: 604354
Other names: T. sibiricus MM 739, Thermococcus sibiricus MM 739, Thermococcus sibiricus str. MM 739, Thermococcus sibiricus strain MM 739
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.