Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TSIB_1371ABC-type multidrug transport system, ATPase component. (329 aa)    
Predicted Functional Partners:
TSIB_1370
ABC-type multidrug transport system, permease component.
 
  
 0.933
TSIB_1369
ABC-type multidrug transport system, permease component.
 
  
 0.929
TSIB_0214
ABC-type multidrug transport system, permease component.
 
  
 0.796
TSIB_1373
Hypothetical protein.
       0.710
TSIB_1982
Daunorubicin resistance ABC transporter membrane protein.
 
  
 0.654
TSIB_0144
Putative ABC transporter.
 
  
 0.582
TSIB_1372
Hypothetical protein.
       0.567
TSIB_0212
Transcription regulator, PadR-like family.
 
    0.469
tfe
Probable archaeal transcription factor, related to transcription factor TFIIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing [...]
       0.446
TSIB_0256
MATE efflux family protein.
  
  
 0.432
Your Current Organism:
Thermococcus sibiricus
NCBI taxonomy Id: 604354
Other names: T. sibiricus MM 739, Thermococcus sibiricus MM 739, Thermococcus sibiricus str. MM 739, Thermococcus sibiricus strain MM 739
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