STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TSIB_16452-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase. (78 aa)    
Predicted Functional Partners:
TSIB_1646
Thiamine pyrophosphate-dependent dehydrogenase, E1 component beta subunit.
  
 0.955
TSIB_1647
Thiamine pyrophosphate-dependent dehydrogenase, E1 component alpha subunit.
 
 0.951
TSIB_1638
Pyruvate dehydrogenase, beta subunit.
  
 0.847
TSIB_1639
Pyruvate dehydrogenase.
  
 0.810
TSIB_1644
Biotin/lipoate A/B protein ligase family protein.
  
 0.805
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
  
 0.720
TSIB_1518
NADH:ubiquinone oxidoreductase, NADH-binding subunit F.
  
 
 0.596
gcvH
Probable glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
 0.583
TSIB_1519
NADH:ubiquinone oxidoreductase, subunit E.
   
 
 0.574
TSIB_1110
Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
  
 0.507
Your Current Organism:
Thermococcus sibiricus
NCBI taxonomy Id: 604354
Other names: T. sibiricus MM 739, Thermococcus sibiricus MM 739, Thermococcus sibiricus str. MM 739, Thermococcus sibiricus strain MM 739
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.