Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tpiATriosephosphate isomerase (TIM); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (224 aa)    
Predicted Functional Partners:
gap
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
 
 0.999
pgk
3-phosphoglycerate kinase (PGK); Belongs to the phosphoglycerate kinase family.
 
 
 0.990
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
 
 0.987
fbp
Fructose-1,6-bisphosphatase (FBP); Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
    
 0.985
TSIB_1686
Glyceraldehyde-3-phosphate:ferredoxin oxidoreductase (GAPOR).
    
 0.974
TSIB_0230
Fructose-1,6-bisphosphate aldolase (FBA).
 
 
 0.966
TSIB_0907
Fuculose-1-phosphate aldolase.
 
  
 0.954
TSIB_1868
Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPN); Belongs to the aldehyde dehydrogenase family.
  
 0.952
TSIB_0348
Enolase.
  
 
 0.949
TSIB_0471
Pyruvate kinase (PYK); Belongs to the pyruvate kinase family.
  
 
 0.942
Your Current Organism:
Thermococcus sibiricus
NCBI taxonomy Id: 604354
Other names: T. sibiricus MM 739, Thermococcus sibiricus MM 739, Thermococcus sibiricus str. MM 739, Thermococcus sibiricus strain MM 739
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