STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TSIB_2009DNA helicase, UvrD/REP family. (716 aa)    
Predicted Functional Partners:
TSIB_0167
Hypothetical protein.
   
 0.770
TSIB_0253
Putative mRNA 3'-end processing factor.
   
 0.722
taw3-2
Hypothetical protein; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family.
 
     0.711
TSIB_1454
Predicted carboxylesterase, alpha/beta hydrolase superfamily.
   
 0.699
rpl3
50S ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
 
 
  0.612
eif2a
Translation initiation factor 2 subunit alpha; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family.
   
 
 0.598
TSIB_0164
Tryptophan/tyrosine permease family.
  
 
 
 0.590
rpl14e
50S ribosomal protein L14e; Belongs to the eukaryotic ribosomal protein eL14 family.
    
 0.569
TSIB_0486
Phosphopantothenoylcysteine synthetase/decarboxylase.
   
 
 0.555
TSIB_1591
Tbp-interacting protein tip49.
  
 
 
 0.551
Your Current Organism:
Thermococcus sibiricus
NCBI taxonomy Id: 604354
Other names: T. sibiricus MM 739, Thermococcus sibiricus MM 739, Thermococcus sibiricus str. MM 739, Thermococcus sibiricus strain MM 739
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.