| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSCSAP00000000080 | ENSCSAP00000010913 | ENSCSAP00000000080 | ENSCSAP00000010913 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.937 |
| ENSCSAP00000000080 | HLTF | ENSCSAP00000000080 | ENSCSAP00000007652 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | Helicase like transcription factor. | 0.884 |
| ENSCSAP00000000080 | LOC103222584 | ENSCSAP00000000080 | ENSCSAP00000018105 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.937 |
| ENSCSAP00000000080 | OTUB1 | ENSCSAP00000000080 | ENSCSAP00000003177 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin thioesterase. | 0.903 |
| ENSCSAP00000000080 | PRKN | ENSCSAP00000000080 | ENSCSAP00000008452 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | Parkin RBR E3 ubiquitin protein ligase. | 0.892 |
| ENSCSAP00000000080 | RBX1 | ENSCSAP00000000080 | ENSCSAP00000002157 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | Ring-box 1. | 0.881 |
| ENSCSAP00000000080 | RNF168 | ENSCSAP00000000080 | ENSCSAP00000004863 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.919 |
| ENSCSAP00000000080 | RNF8 | ENSCSAP00000000080 | ENSCSAP00000006706 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.918 |
| ENSCSAP00000000080 | TRAF6 | ENSCSAP00000000080 | ENSCSAP00000001791 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.950 |
| ENSCSAP00000000080 | UBA1 | ENSCSAP00000000080 | ENSCSAP00000009833 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | 0.896 |
| ENSCSAP00000010913 | ENSCSAP00000000080 | ENSCSAP00000010913 | ENSCSAP00000000080 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.937 |
| ENSCSAP00000010913 | HLTF | ENSCSAP00000010913 | ENSCSAP00000007652 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Helicase like transcription factor. | 0.833 |
| ENSCSAP00000010913 | OTUB1 | ENSCSAP00000010913 | ENSCSAP00000003177 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Ubiquitin thioesterase. | 0.572 |
| ENSCSAP00000010913 | PRKN | ENSCSAP00000010913 | ENSCSAP00000008452 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Parkin RBR E3 ubiquitin protein ligase. | 0.566 |
| ENSCSAP00000010913 | RBX1 | ENSCSAP00000010913 | ENSCSAP00000002157 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Ring-box 1. | 0.576 |
| ENSCSAP00000010913 | RNF168 | ENSCSAP00000010913 | ENSCSAP00000004863 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.819 |
| ENSCSAP00000010913 | RNF8 | ENSCSAP00000010913 | ENSCSAP00000006706 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.711 |
| ENSCSAP00000010913 | TRAF6 | ENSCSAP00000010913 | ENSCSAP00000001791 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.552 |
| ENSCSAP00000010913 | UBA1 | ENSCSAP00000010913 | ENSCSAP00000009833 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | 0.589 |
| HLTF | ENSCSAP00000000080 | ENSCSAP00000007652 | ENSCSAP00000000080 | Helicase like transcription factor. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.884 |
