| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APP | NAE1 | ENSCSAP00000005302 | ENSCSAP00000000950 | Amyloid beta precursor protein. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.981 |
| CACUL1 | CUL1 | ENSCSAP00000001110 | ENSCSAP00000003333 | CDK2 associated cullin domain 1; Belongs to the cullin family. | Cullin 1; Belongs to the cullin family. | 0.621 |
| CACUL1 | CUL5 | ENSCSAP00000001110 | ENSCSAP00000015038 | CDK2 associated cullin domain 1; Belongs to the cullin family. | Cullin 5; Belongs to the cullin family. | 0.649 |
| CACUL1 | ENSCSAP00000018574 | ENSCSAP00000001110 | ENSCSAP00000018574 | CDK2 associated cullin domain 1; Belongs to the cullin family. | Ubiquitin-like domain-containing protein. | 0.858 |
| CACUL1 | NAE1 | ENSCSAP00000001110 | ENSCSAP00000000950 | CDK2 associated cullin domain 1; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.722 |
| CACUL1 | TRIP12 | ENSCSAP00000001110 | ENSCSAP00000003303 | CDK2 associated cullin domain 1; Belongs to the cullin family. | Thyroid hormone receptor interactor 12. | 0.545 |
| CACUL1 | UBA3 | ENSCSAP00000001110 | ENSCSAP00000007844 | CDK2 associated cullin domain 1; Belongs to the cullin family. | Ubiquitin like modifier activating enzyme 3. | 0.710 |
| CACUL1 | UBE2M | ENSCSAP00000001110 | ENSCSAP00000016441 | CDK2 associated cullin domain 1; Belongs to the cullin family. | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. | 0.757 |
| CUL1 | CACUL1 | ENSCSAP00000003333 | ENSCSAP00000001110 | Cullin 1; Belongs to the cullin family. | CDK2 associated cullin domain 1; Belongs to the cullin family. | 0.621 |
| CUL1 | CUL3 | ENSCSAP00000003333 | ENSCSAP00000003972 | Cullin 1; Belongs to the cullin family. | Cullin 3; Belongs to the cullin family. | 0.873 |
| CUL1 | CUL5 | ENSCSAP00000003333 | ENSCSAP00000015038 | Cullin 1; Belongs to the cullin family. | Cullin 5; Belongs to the cullin family. | 0.540 |
| CUL1 | ENSCSAP00000018574 | ENSCSAP00000003333 | ENSCSAP00000018574 | Cullin 1; Belongs to the cullin family. | Ubiquitin-like domain-containing protein. | 0.987 |
| CUL1 | NAE1 | ENSCSAP00000003333 | ENSCSAP00000000950 | Cullin 1; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.803 |
| CUL1 | TRIP12 | ENSCSAP00000003333 | ENSCSAP00000003303 | Cullin 1; Belongs to the cullin family. | Thyroid hormone receptor interactor 12. | 0.552 |
| CUL1 | UBA3 | ENSCSAP00000003333 | ENSCSAP00000007844 | Cullin 1; Belongs to the cullin family. | Ubiquitin like modifier activating enzyme 3. | 0.929 |
| CUL1 | UBE2M | ENSCSAP00000003333 | ENSCSAP00000016441 | Cullin 1; Belongs to the cullin family. | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. | 0.970 |
| CUL3 | CUL1 | ENSCSAP00000003972 | ENSCSAP00000003333 | Cullin 3; Belongs to the cullin family. | Cullin 1; Belongs to the cullin family. | 0.873 |
| CUL3 | CUL5 | ENSCSAP00000003972 | ENSCSAP00000015038 | Cullin 3; Belongs to the cullin family. | Cullin 5; Belongs to the cullin family. | 0.656 |
| CUL3 | ENSCSAP00000018574 | ENSCSAP00000003972 | ENSCSAP00000018574 | Cullin 3; Belongs to the cullin family. | Ubiquitin-like domain-containing protein. | 0.989 |
| CUL3 | NAE1 | ENSCSAP00000003972 | ENSCSAP00000000950 | Cullin 3; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.715 |
