Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
THAP6THAP domain containing 6. (222 aa)    
Predicted Functional Partners:
PRKAR1A
Protein kinase cAMP-dependent type I regulatory subunit alpha.
   
 0.583
CNBD2
Cyclic nucleotide binding domain containing 2.
   
 0.583
PRKAR2B
Protein kinase cAMP-dependent type II regulatory subunit beta.
   
 0.583
PRKAR2A
Protein kinase cAMP-dependent type II regulatory subunit alpha.
   
 0.583
PRKAR1B
Protein kinase cAMP-dependent type I regulatory subunit beta.
   
 0.583
SUFU
Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]
    
 0.550
TREH
Trehalase.
   
 
 0.499
THAP5
THAP domain containing 5.
   
 0.482
CALHM2
Calcium homeostasis modulator family member 2.
   
    0.479
CALHM4
Calcium homeostasis modulator family member 4.
   
    0.479
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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