Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CCNE1Cyclin E1; Belongs to the cyclin family. (416 aa)    
Predicted Functional Partners:
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.998
CDK3
Cyclin dependent kinase 3; Belongs to the protein kinase superfamily.
   
 0.987
CDK6
Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.
   
 0.979
CDK4
Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.977
CDKN1B
Cyclin dependent kinase inhibitor 1B.
   
 0.975
CDKN1A
Cyclin dependent kinase inhibitor 1A.
   
 0.973
RB1
RB transcriptional corepressor 1.
   
 0.970
PCNA
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 
 0.965
FBXW7
F-box and WD repeat domain containing 7.
    
 0.958
CDK1
Protein kinase domain-containing protein.
   
 0.941
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.