| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APOE | APP | ENSCSAP00000014799 | ENSCSAP00000005302 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Amyloid beta precursor protein. | 0.850 |
| APOE | HSP90B1 | ENSCSAP00000014799 | ENSCSAP00000014983 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Heat shock protein 90 beta family member 1. | 0.510 |
| APOE | LPL | ENSCSAP00000014799 | ENSCSAP00000012759 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. | 0.913 |
| APOE | LRP1 | ENSCSAP00000014799 | ENSCSAP00000001271 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | LDL receptor related protein 1. | 0.976 |
| APOE | LRP2 | ENSCSAP00000014799 | ENSCSAP00000011332 | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | LDL receptor related protein 2. | 0.970 |
| APP | APOE | ENSCSAP00000005302 | ENSCSAP00000014799 | Amyloid beta precursor protein. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.850 |
| APP | LRP1 | ENSCSAP00000005302 | ENSCSAP00000001271 | Amyloid beta precursor protein. | LDL receptor related protein 1. | 0.670 |
| HPX | LRP1 | ENSCSAP00000000664 | ENSCSAP00000001271 | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. | LDL receptor related protein 1. | 0.759 |
| HSP90AA1 | HSP90AB1 | ENSCSAP00000006483 | ENSCSAP00000008609 | HATPase_c domain-containing protein. | Heat shock protein 90 alpha family class B member 1. | 0.991 |
| HSP90AA1 | HSP90B1 | ENSCSAP00000006483 | ENSCSAP00000014983 | HATPase_c domain-containing protein. | Heat shock protein 90 beta family member 1. | 0.929 |
| HSP90AA1 | LRP1 | ENSCSAP00000006483 | ENSCSAP00000001271 | HATPase_c domain-containing protein. | LDL receptor related protein 1. | 0.683 |
| HSP90AB1 | HSP90AA1 | ENSCSAP00000008609 | ENSCSAP00000006483 | Heat shock protein 90 alpha family class B member 1. | HATPase_c domain-containing protein. | 0.991 |
| HSP90AB1 | HSP90B1 | ENSCSAP00000008609 | ENSCSAP00000014983 | Heat shock protein 90 alpha family class B member 1. | Heat shock protein 90 beta family member 1. | 0.931 |
| HSP90AB1 | LRP1 | ENSCSAP00000008609 | ENSCSAP00000001271 | Heat shock protein 90 alpha family class B member 1. | LDL receptor related protein 1. | 0.676 |
| HSP90B1 | APOE | ENSCSAP00000014983 | ENSCSAP00000014799 | Heat shock protein 90 beta family member 1. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.510 |
| HSP90B1 | HSP90AA1 | ENSCSAP00000014983 | ENSCSAP00000006483 | Heat shock protein 90 beta family member 1. | HATPase_c domain-containing protein. | 0.929 |
| HSP90B1 | HSP90AB1 | ENSCSAP00000014983 | ENSCSAP00000008609 | Heat shock protein 90 beta family member 1. | Heat shock protein 90 alpha family class B member 1. | 0.931 |
| HSP90B1 | LRP1 | ENSCSAP00000014983 | ENSCSAP00000001271 | Heat shock protein 90 beta family member 1. | LDL receptor related protein 1. | 0.660 |
| HSP90B1 | LRP2 | ENSCSAP00000014983 | ENSCSAP00000011332 | Heat shock protein 90 beta family member 1. | LDL receptor related protein 2. | 0.431 |
| LPL | APOE | ENSCSAP00000012759 | ENSCSAP00000014799 | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.913 |