| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHEK1 | MCM7 | ENSCSAP00000015742 | ENSCSAP00000013867 | Checkpoint kinase 1. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.884 |
| CHEK1 | RPA1 | ENSCSAP00000015742 | ENSCSAP00000009979 | Checkpoint kinase 1. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.594 |
| CHEK1 | RPA3 | ENSCSAP00000015742 | ENSCSAP00000009292 | Checkpoint kinase 1. | Replication protein A3. | 0.641 |
| CHEK1 | TIMELESS | ENSCSAP00000015742 | ENSCSAP00000001412 | Checkpoint kinase 1. | Timeless circadian regulator. | 0.924 |
| CHEK1 | TIPIN | ENSCSAP00000015742 | ENSCSAP00000009317 | Checkpoint kinase 1. | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. | 0.767 |
| CHEK1 | WDHD1 | ENSCSAP00000015742 | ENSCSAP00000010793 | Checkpoint kinase 1. | WD repeat and HMG-box DNA binding protein 1. | 0.482 |
| CRY1 | PER2 | ENSCSAP00000015109 | ENSCSAP00000002330 | Cryptochrome circadian regulator 1. | Period circadian regulator 2. | 0.999 |
| CRY1 | TIMELESS | ENSCSAP00000015109 | ENSCSAP00000001412 | Cryptochrome circadian regulator 1. | Timeless circadian regulator. | 0.947 |
| GINS3 | MCM7 | ENSCSAP00000001076 | ENSCSAP00000013867 | GINS complex subunit 3. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.970 |
| GINS3 | TIMELESS | ENSCSAP00000001076 | ENSCSAP00000001412 | GINS complex subunit 3. | Timeless circadian regulator. | 0.944 |
| GINS3 | TIPIN | ENSCSAP00000001076 | ENSCSAP00000009317 | GINS complex subunit 3. | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. | 0.939 |
| GINS3 | WDHD1 | ENSCSAP00000001076 | ENSCSAP00000010793 | GINS complex subunit 3. | WD repeat and HMG-box DNA binding protein 1. | 0.864 |
| MCM7 | CHEK1 | ENSCSAP00000013867 | ENSCSAP00000015742 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Checkpoint kinase 1. | 0.884 |
| MCM7 | GINS3 | ENSCSAP00000013867 | ENSCSAP00000001076 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | GINS complex subunit 3. | 0.970 |
| MCM7 | RPA1 | ENSCSAP00000013867 | ENSCSAP00000009979 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.908 |
| MCM7 | RPA3 | ENSCSAP00000013867 | ENSCSAP00000009292 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Replication protein A3. | 0.740 |
| MCM7 | TIMELESS | ENSCSAP00000013867 | ENSCSAP00000001412 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Timeless circadian regulator. | 0.961 |
| MCM7 | TIPIN | ENSCSAP00000013867 | ENSCSAP00000009317 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. | 0.959 |
| MCM7 | WDHD1 | ENSCSAP00000013867 | ENSCSAP00000010793 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | WD repeat and HMG-box DNA binding protein 1. | 0.927 |
| PER2 | CRY1 | ENSCSAP00000002330 | ENSCSAP00000015109 | Period circadian regulator 2. | Cryptochrome circadian regulator 1. | 0.999 |
