STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SOAT2O-acyltransferase. (528 aa)    
Predicted Functional Partners:
DHCR24
24-dehydrocholesterol reductase.
     
 0.937
DHCR7
7-dehydrocholesterol reductase.
    
 0.930
CYP7A1
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
   
 
 0.915
SOAT1
O-acyltransferase.
  
  
0.908
CH25H
Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.
   
 0.873
CYP46A1
Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family.
    
 0.872
CYP27A1
Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family.
   
 
 0.846
LCAT
Lecithin-cholesterol acyltransferase.
    
 
 0.827
STS
Steroid sulfatase.
   
 
  0.811
CYP11A1
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
   
 
 0.808
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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