TWNK protein (Chlorocebus sabaeus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

TWNK

Twinkle mtDNA helicase. (684 aa)

Predicted Functional Partners:

POLG

0.901

POLG2

0.888

POLRMT

0.860

SSBP1

0.844

NUBPL

0.783

CPOX

0.764

TFAM

0.752

PTGES2

0.718

RMND1

0.670

LONP1

0.617

Your Current Organism:

Chlorocebus sabaeus

NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPOX	TWNK	ENSCSAP00000002305	ENSCSAP00000001858	Coproporphyrinogen oxidase.	Twinkle mtDNA helicase.	0.764
LONP1	POLRMT	ENSCSAP00000006154	ENSCSAP00000009039	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...]	DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.	0.577
LONP1	SSBP1	ENSCSAP00000006154	ENSCSAP00000004366	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...]	Single stranded DNA binding protein 1.	0.647
LONP1	TFAM	ENSCSAP00000006154	ENSCSAP00000003557	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...]	Transcription factor A, mitochondrial.	0.809
LONP1	TWNK	ENSCSAP00000006154	ENSCSAP00000001858	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...]	Twinkle mtDNA helicase.	0.617
NUBPL	TWNK	ENSCSAP00000011774	ENSCSAP00000001858	Nucleotide binding protein like.	Twinkle mtDNA helicase.	0.783
POLG	POLG2	ENSCSAP00000013203	ENSCSAP00000000373	DNA polymerase gamma, catalytic subunit.	DNA polymerase gamma 2, accessory subunit.	0.999
POLG	POLRMT	ENSCSAP00000013203	ENSCSAP00000009039	DNA polymerase gamma, catalytic subunit.	DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.	0.830
POLG	SSBP1	ENSCSAP00000013203	ENSCSAP00000004366	DNA polymerase gamma, catalytic subunit.	Single stranded DNA binding protein 1.	0.894
POLG	TFAM	ENSCSAP00000013203	ENSCSAP00000003557	DNA polymerase gamma, catalytic subunit.	Transcription factor A, mitochondrial.	0.636
POLG	TWNK	ENSCSAP00000013203	ENSCSAP00000001858	DNA polymerase gamma, catalytic subunit.	Twinkle mtDNA helicase.	0.901
POLG2	POLG	ENSCSAP00000000373	ENSCSAP00000013203	DNA polymerase gamma 2, accessory subunit.	DNA polymerase gamma, catalytic subunit.	0.999
POLG2	POLRMT	ENSCSAP00000000373	ENSCSAP00000009039	DNA polymerase gamma 2, accessory subunit.	DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.	0.923
POLG2	SSBP1	ENSCSAP00000000373	ENSCSAP00000004366	DNA polymerase gamma 2, accessory subunit.	Single stranded DNA binding protein 1.	0.871
POLG2	TFAM	ENSCSAP00000000373	ENSCSAP00000003557	DNA polymerase gamma 2, accessory subunit.	Transcription factor A, mitochondrial.	0.537
POLG2	TWNK	ENSCSAP00000000373	ENSCSAP00000001858	DNA polymerase gamma 2, accessory subunit.	Twinkle mtDNA helicase.	0.888
POLRMT	LONP1	ENSCSAP00000009039	ENSCSAP00000006154	DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...]	0.577
POLRMT	POLG	ENSCSAP00000009039	ENSCSAP00000013203	DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.	DNA polymerase gamma, catalytic subunit.	0.830
POLRMT	POLG2	ENSCSAP00000009039	ENSCSAP00000000373	DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.	DNA polymerase gamma 2, accessory subunit.	0.923
POLRMT	RMND1	ENSCSAP00000009039	ENSCSAP00000010385	DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.	Required for meiotic nuclear division 1 homolog.	0.485

page 1 of 3

Server load: low (26%) [HD]

Permalink

Network

Neighborhood

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About