STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)    
Predicted Functional Partners:
CDK5
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
 0.998
MAPT
Microtubule-associated protein.
   
 0.926
CAPN2
Calpain 2; Belongs to the peptidase C2 family.
   
 
 0.912
VSNL1
Visinin like 1.
   
  
 0.675
ATN1
Atrophin 1.
      
 0.617
PSENEN
Presenilin enhancer, gamma-secretase subunit.
      
 0.579
CDK14
Cyclin dependent kinase 14; Belongs to the protein kinase superfamily.
    
 
 0.553
MET
MET proto-oncogene, receptor tyrosine kinase.
   
  0.528
MST1R
Macrophage stimulating 1 receptor.
   
  0.528
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
     
 0.524
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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