STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)    
Predicted Functional Partners:
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
 
 0.973
AMFR
Autocrine motility factor receptor.
    
 
 0.966
SCAP
SREBF chaperone.
    
 0.964
SREBF2
Sterol regulatory element binding transcription factor 2.
   
 0.897
VCP
Valosin containing protein; Belongs to the AAA ATPase family.
   
 
 0.848
ERLIN2
ER lipid raft associated 2.
    
 
 0.807
RNF139
Ring finger protein 139.
    
 
 0.806
FAF2
Fas associated factor family member 2.
    
 
 0.799
SREBF1
Sterol regulatory element binding transcription factor 1.
   
 0.751
GRB14
Growth factor receptor bound protein 14.
      
 0.713
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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