STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (978 aa)    
Predicted Functional Partners:
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.968
APP
Amyloid beta precursor protein.
    
 
 0.928
IAPP
Islet amyloid polypeptide.
    
 
 0.907
MMEL1
Membrane metalloendopeptidase like 1.
   
  
 0.856
GCG
Glucagon.
    
 
 0.848
IGF2
Insulin like growth factor 2.
    
 
 0.811
MME
Membrane metalloendopeptidase.
      
 0.808
NPPA
Natriuretic peptide A.
    
 
 0.763
TGFA
Transforming growth factor alpha.
    
 
 0.747
NPPB
Natriuretic peptide B.
    
 
 0.747
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.