Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPICE1Uncharacterized protein. (858 aa)    
Predicted Functional Partners:
MRAP
Melanocortin 2 receptor accessory protein.
   
    0.964
LUM
Lumican.
      
 0.888
GRIN3A
Glutamate ionotropic receptor NMDA type subunit 3A.
      
 0.856
CIB1
Calcium and integrin binding 1.
      
 0.852
HTR5A
5-hydroxytryptamine receptor 5A.
      
 0.849
CRADD
Death domain-containing protein.
      
 0.816
CEP295
Centrosomal protein 295.
   
 
 0.804
MCM7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
      
 0.782
NXPE3
Neurexophilin and PC-esterase domain family member 3.
    
   0.768
NEDD9
Neural precursor cell expressed, developmentally down-regulated 9.
      
 0.767
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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