STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EPORErythropoietin receptor; Receptor for erythropoietin. (511 aa)    
Predicted Functional Partners:
JAK2
Tyrosine-protein kinase.
    
 0.999
EPO
Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.
    
 0.989
JAK3
Tyrosine-protein kinase.
    
 0.975
STAT5A
Signal transducer and activator of transcription.
    
 0.970
JAK1
Tyrosine-protein kinase.
    
 0.951
STAT5B
Signal transducer and activator of transcription.
    
 0.941
LEPR
Leptin receptor.
     
 0.931
CSF3R
Colony stimulating factor 3 receptor.
     
 0.928
MPL
MPL proto-oncogene, thrombopoietin receptor.
     
0.921
GHR
Growth hormone receptor.
   
 
 0.912
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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