Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FGD3FYVE, RhoGEF and PH domain containing 3. (737 aa)    
Predicted Functional Partners:
CDC42
Cell division cycle 42.
   
 0.974
FGD1
FYVE, RhoGEF and PH domain containing 1.
     
 
0.907
GNG12
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
     
 0.906
FGD4
FYVE, RhoGEF and PH domain containing 4.
    
 0.724
MRAP
Melanocortin 2 receptor accessory protein.
      
 0.521
PNN
Pinin, desmosome associated protein.
      
 0.498
TLCD3B
TLC domain containing 3B.
      
 0.478
TCEA2
Transcription elongation factor A2.
      
 0.477
WNK3
WNK lysine deficient protein kinase 3.
   
  
 0.475
ITSN2
Intersectin 2.
     
 0.465
Your Current Organism:
Chlorocebus sabaeus
NCBI taxonomy Id: 60711
Other names: C. sabaeus, Cercopithecus aethiops sabaeus, Cercopithecus sabaeus, Cercopithecus sabeus, Chlorocebus aethiops sabaeus, Chlorocebus aethiops sabeus, Chlorocebus sabeus, green monkey
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